chronic respiratory disorders due to sulfur mustard inhalation. Chronic respiratory conditions due to chemicals, gases, fumes and vapors
Conditions
Interventions
Intervention 1: Intervention: Pulmonary rehabilitation will be a mix of aerobic endurance training and strength training as well as education in self management. Patients will attend 3 times per week
Sponsors
Health Department of Foundation of Martyrs and Veterans Affairs
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: patients with history of sulfur mustard exposure FEV1 lower than 80% predicted MRC dyspnoea score = 3
Exclusion criteria
Exclusion criteria: any type of debilitating clinical condition that prevents the patient from participating in the rehabilitation program –such as, arthritis any type of clinical condition that will endanger the patient during the physical exercises –such as, uncontrolled cardiac diseases the presence of other non-chemical related pulmonary diseases like asthma active malignancy severe cognitive disorder and psychiatric disease that is associated with memory disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endurance Time. Timepoint: before intervention , 6th week, 12th month. Method of measurement: by using an electronically braked cycle ergometer at 70% of Wmax to volitional exhaustion. | — |
Secondary
| Measure | Time frame |
|---|---|
| Lung flows and volumes. Timepoint: before intervention , 6th week, 12th month. Method of measurement: by using body plethysmography.;Single-breath diffusing capacity. Timepoint: before intervention , 6th week, 12th month. Method of measurement: by using DLCO.;Vo2max. Timepoint: before intervention. Method of measurement: by using ergospirometry.;Quadriceps muscle strength. Timepoint: before intervention , 6th week, 12th month. Method of measurement: by using Biodex: Participants will perform 30 sequential volitional maximal contractions at an angular velocity of 90°/s, while seated upright and with the hip joint in 90° of flexion. Quadriceps muscle strength was defined as the highest peak torque (Newton-meter (Nm)).;AT. Timepoint: before intervention. Method of measurement: by using ergospirometry.;O2 pulse. Timepoint: before intervention. Method of measurement: by using ergospirometry.;Quadriceps muscle endurance. Timepoint: before intervention , 6th week, 12th month. Method of measurement: by using Biodex: Participants will perform 30 sequential volitional maximal contractions at an angular velocity of 90°/s, while seated upright and with the hip joint in 90° of flexion. Quadriceps muscle endurance was defined as the total amount of delivered work (Joules (J)) during the set of 30 repetitions.;Cross-sectional area of the rectus femoris (RFCSA). Timepoint: before intervention , 6th week, 12th month. Method of measurement: by Cross-sectional area of the rectus femoris (RFCSA) will be measured by B-mode ultrasonography using an 8 MHz 5.6 cm linear transducer, similar to the method of de Bruin et al.;FFM. Timepoint: before intervention , 6th week, 12th month. Method of measurement: by using single-frequency BIA (Bioelectrical Impedance Analyser).;BMI. Timepoint: before intervention , 6th week, 12th month. Method of measurement: weight(kg)/height^2(m^2).;Total distance walked during 6 minutes. Timepoint: before intervention , 6th week, 12th month. Method of measurement | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohamad Reza Sedighi Moghadam MD. MPH
Janbazan Medical Engineering Research Center
Outcome results
None listed