diabetes mellitus type2. Non-insulin-dependent diabetes mellitus
Conditions
Interventions
Intervention 1: Pearl of vitaminD 50000IU weekly for 8 weeks. Intervention 2: Placebo of edible paraffin and similar to vitaminD3.
Prevention
Placebo
Pearl of vitaminD 50000IU weekly for 8 weeks
Sponsors
Vice Chancellor for research of Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
25 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Diabetes type2 in both sexes; 25 to 65 years; Serum 25 hydroxy vitaminD3 levels less than 30 nano grams per milliliter (ng/ml); Body mass index (BMI) between 25 to 35 kilograms per square meter (kg/m²); glycated hemoglobin (HbA1c) level less than 8.5%; Willingness to participate in the project Exclusion criteria: Insulin consumption; Smoking or drinking alcohol at least once a week; Regular consumption of (at least once a week) herbal, antioxidant, multivitamin mineral, vitaminD3 and omega3 supplements; Taking birth control pills and Nonsteroidal antiiflammatory drugs (NSAIDs) in the last three months; Pregnancy and lactatin; Diagnosed diseases such as cancer, digestive diseases, liver and kidney diseases, autoimmune diseases, inflammation, hypothyroidism, polycystic ovarian syndrome; Changing usual and balanced diet with vegetarian diets or single product or any other unusual changes in the last three months; triglyceride levels more than 250 Milligrams per deciliter (mg/dl) and cholesterol more than 300 mg/dl; Exposure to sun and use of solarium for tanning up to 3 months before the start of the study; Taking medications affecting vitaminD3 metabolism such as Antiepileptic drugs and corticosteroids; Consuming less than 90% of supplements; Suffering from any acute illness; Any change in the type and amount of blood glucose lowering drugs
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HbA1c. Timepoint: Before and 8 weeks after intervention. Method of measurement: Laboratory kit.;Fasting blood sugar. Timepoint: Before and 8 weeks after intervention. Method of measurement: Laboratory kit.;Lipid profile. Timepoint: Before and 8 weeks after intervention. Method of measurement: Laboratory kit.;Blood pressur. Timepoint: Before and 8 weeks after intervention. Method of measurement: Barometer.;Liver indices. Timepoint: Before and 8 weeks after intervention. Method of measurement: Laboratory kit.;Kidney indices. Timepoint: Before and 8 weeks after intervention. Method of measurement: Laboratory kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum 25(OH)D3 Level. Timepoint: Before and 8 weeks after intervention. Method of measurement: Laboratory Kit.;Fasting Insulin. Timepoint: Before and 8 weeks after intervention. Method of measurement: laboratory Kit.;Insulin resistance. Timepoint: Before and 8 weeks after intervention. Method of measurement: HOMA-IR formula. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Reza Vafa
Iran University of Medical Sciences
Outcome results
None listed