Drug induced nephropathy. Nephropathy induced by other drugs, medicaments and biological substances
Conditions
Interventions
Intervention 1: Lycopene 25mg tablet bid 24hr before until 72hr left after cisplatin injection and an standard regimen of kidney injury prevention (hydration+sulphate magnesium). Intervention 2: Cispl
Treatment - Drugs
Lycopene 25mg tablet bid 24hr before until 72hr left after cisplatin injection and an standard regimen of kidney injury prevention (hydration+sulphate magnesium).
Cisplatin and an standard regimen of kidney injury prevention (hydration+sulphate magnesium).
Sponsors
Vice chancellor for research, Shahrekord university of medical sciences
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria were condidered to be suffering cancer without primary involvement or renal metastasis; being candidate for administration of 70-100 mg/m2 cisplatin; being 20-80 years old; Cr < 1.5; normal hearing; no underlying nephropathy; ; performance status of 0-2. Exclusion criteria were death; allergy to lycopene; hearing loss; moderate to severe neuropathy; renal metastatic involvement.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BUN. Timepoint: Before intervention, 7 & 21 days lft. Method of measurement: mg/dl - labratuary.;Cr. Timepoint: Before intervention, 7 & 21 days lft. Method of measurement: mg/dl - labratuary.;GFR. Timepoint: Before intervention, 7 & 21 days lft. Method of measurement: ml/min - calculation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactKeivan Mohammadi
Shahrekord university of medical sciences
Outcome results
None listed