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Evaluation the effect of clonidine and dexmedetomidine administration on bleeding during surgery

The effect of oral clonidine and intravenous dexmedetomidine administration on bleeding during functional endoscopic sinus surgery

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160430027677N20
Enrollment
64
Registered
2020-11-02
Start date
2019-05-22
Completion date
Unknown
Last updated
2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bleeding.

Interventions

Intervention 1: Intervention group: patients will receive Clonidine 200 mcg oral tablet, 90 minutes before surgery. Intervention 2: Intervention group: Patients in Group dexmedetomidine will be receiv

Sponsors

Oroumia University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Aged 20-60 years old American Society of Anesthesiologists physical status classification I,II General anesthesia

Exclusion criteria

Exclusion criteria: Patients with diabetes mellitus Coagulation problems Liver or kidney failure Cerebrovascular disease High blood pressure Asthma Chronic obstructive pulmonary disease Severe end organ damage Psychosis Patients receiving antipsychotic medication Hypersensitivity to dexmedetomidine and clonidine Drug abusers Use of beta blockers drugs Heart rate less than 55 beats per minute

Design outcomes

Primary

MeasureTime frame
Amount of bleeding. Timepoint: during surgery. Method of measurement: Measuring the amount of blood inside the suction device and the gases used.;Quality of the surgical field. Timepoint: During surgery. Method of measurement: Boezaart scale.

Secondary

MeasureTime frame
Mean arterial pressure. Timepoint: Every 5 minutes during the surgery. Method of measurement: Non invasive pressure gauge.;Mean pulse Rate. Timepoint: Every 5 minutes during the surgery. Method of measurement: Electrocardiogram.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahryar Sane

Oroumia University of Medical Sciences

sanesh@umsu.ac.ir+98 44 3223 4897

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026