The effect of Tizanidine premedication on blood loss and the quality of the surgical field

Comparison the effect of oral Tizanidine and placebo on blood loss and the quality of the surgical field during endoscopic paranasal sinus surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160430027677N12

Enrollment

Registered

2019-02-22

Start date

2016-05-20

Completion date

Unknown

Last updated

2019-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bleeding.

Interventions

Intervention 1: Intervention group: patients will receive tizanidine 6 mg oral tablet, 90 minutes before surgery. Intervention 2: Control group: will receive oral placebo 90 minutes before surgery.

Eligibility

Sex/Gender

All

Age

25 Years to 55 Years

Inclusion criteria

Inclusion criteria: Being at the age of 25 to 55 years old ASA (American Society of Anesthesiologists) class I Chronic sinusitis

Exclusion criteria

Exclusion criteria: Patients in whom controlled decreasing blood pressure is contraindicated Liver and kidney failure Known sensitivity to tizanidine Systolic blood pressure above 160 and diastolic blood pressure above 90 mmhg Heart rate below 50 per minute Patients who have received anticoagulant, beta blocker, calcium channel blocker or digoxin

Design outcomes

Primary

Measure	Time frame
Amount of bleeding. Timepoint: during surgery. Method of measurement: Measuring the amount of blood inside the suction device and the gases used.;Quality of the surgical field. Timepoint: During surgery. Method of measurement: Boezaart scale.	—

Secondary

Measure	Time frame
Pain. Timepoint: At recovery and 6 hours after surgery. Method of measurement: visual analog scale.;Mean arterial pressure. Timepoint: Every 15 minutes during surgery. Method of measurement: Non invasive pressure gauge.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahryar Sane

Oroumia University of Medical Sciences

sanesh@umsu.ac.ir+98 44 3223 4897

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026