Effectiveness of L-Carnitine in improvement of liver enzyme in patients treated with Methotrexate and 6-Mercaptopurine. Treatment

Comparison the effectiveness and non effectiveness of L-carnitine in improvement of liver enzymes in patients treated with methotrexate and 6-mercaptopurine

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201604297677N5

Enrollment

Registered

2016-05-10

Start date

2016-05-14

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute lymphoblastic leukemia. Acute lymphoblastic leukaemia [ALL]

Interventions

Intervention 1: Folic acid supplements are given to patients in both groups. In the intervention group 50 mg of L-Carnitine tablets or syrup per kg body weight up to2 grams is prescribed daily for 3

Treatment - Drugs

Placebo

Folic acid supplements are given to patients in both groups. In the intervention group 50 mg of L-Carnitine tablets or syrup per kg body weight up to2 grams is prescribed daily for 3 months under th

The control group will received placebo daily 50 mg per kg of body weight up to 2 grams for 3 months.

Eligibility

Sex/Gender

All

Age

1 Years to 18 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age less than 18 years; Patient informed consent . Exclusion criteria: Patients with hypothyroidism –seizures; L-carnitine intolerance.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Aspartat Aminotransferase (AST). Timepoint: Once every two weeks for 3 months. Method of measurement: Based on blood test.;Alanin Aminotransferase (ALT). Timepoint: Once every two weeks for 3 months. Method of measurement: By blood test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Elaham Pourazar

Kermanshah University of Medical Sciences

pourazar.emd81@gmail.com+98 83 3721 8202

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026