The effect of branched chain amino acids and vitamin B6 on weight loss

The effect of simultaneous oral supplementation with branched chain amino acids and vitamin B6 on body composition, insulin resistance index, serum lipid profile, lipocalin-2 and interleukin-18 in overweight and class1 obese women receiving hypocaloric diet.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016042813678N12

Enrollment

Registered

2016-06-29

Start date

2016-07-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: obesity. Condition 2: overweight. Obesity due to excess calories Obesity, unspecified

Interventions

Intervention 1: BCAA caplets, 1 gr, 3 times a day , 2 caplets each time, for a month. Intervention 2: placebo caplets of BCAA, 1 gr, 3 times a day, 2 caplets each time, for a month.

Treatment - Drugs

Placebo

BCAA caplets, 1 gr, 3 times a day , 2 caplets each time, for a month

placebo caplets of BCAA, 1 gr, 3 times a day, 2 caplets each time, for a month

Eligibility

Sex/Gender

Female

Age

13 Years to 55 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: female, Childbearing age, BMI=25-35 kg/m², no pregnancy or lactation, absence of endocrinal, thyroid, metabolic and intestinal diseases and diabetes, no follow of specific diet, no follow of heavy sports, no change in cigarettes and caffeine consumption pattern during 4 weeks before study lunch, no weight loss more than 4.5 kg during 2 month before study lunch, no use of any supplementation and eight loss drugs and OCP during and 4 weeks before study, no significant weight change one week before study lunch. Exclusion criteria: any drug or diet side effects, unwillingness to continue the study, pregnancy, menopause, physical activity and diet changes, diseases.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Body composition. Timepoint: before intervention, 2 weeks after intervention and after interventioin. Method of measurement: BIA analyzer.;Insulin resistance index. Timepoint: before and after intervention. Method of measurement: HOMA-IR formula.;Lipocalin-2. Timepoint: before and after intervention. Method of measurement: ng/l- Serum samples test.;Interleukin-18. Timepoint: before and after intervention. Method of measurement: ng/l- Serum samples test.;Lipid profile. Timepoint: before and after intervention. Method of measurement: Serum samples test.	—

Measure

Time frame

Body composition. Timepoint: before intervention, 2 weeks after intervention and after interventioin. Method of measurement: BIA analyzer.;Insulin resistance index. Timepoint: before and after intervention. Method of measurement: HOMA-IR formula.;Lipocalin-2. Timepoint: before and after intervention. Method of measurement: ng/l- Serum samples test.;Interleukin-18. Timepoint: before and after intervention. Method of measurement: ng/l- Serum samples test.;Lipid profile. Timepoint: before and after intervention. Method of measurement: Serum samples test.

—

Secondary

Measure	Time frame
Waist–hip ratio. Timepoint: before and after intervention. Method of measurement: tape measure.	—

Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026