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The effect of clomiphene N-acetyl cysteine on the pregnancy rate

Comparing pregnancy rate with N-acetyl cysteine plus clomiphene citrate versus clomiphene alone in treatment of polycystic ovary syndrome

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016042727638N1
Enrollment
70
Registered
2016-10-31
Start date
2015-11-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PCO syndrome. Polycystic ovarian syndrome

Interventions

Intervention 1: intervention group: received 100 mg Clomiphene (two 50 mg tablets) with 1200 mg N-acetyl cysteine (two 600 mg tablets) produced by Fluid UI MUCIL company for 5 days. Intervention 2: co
Treatment - Drugs
intervention group: received 100 mg Clomiphene (two 50 mg tablets) with 1200 mg N-acetyl cysteine (two 600 mg tablets) produced by Fluid UI MUCIL company for 5 days
control group: were given only 100 mg clomiphene (two 50 mg tablets) on the third day of the cycle for 5 days

Sponsors

Vice President of Research Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria: PCO patients having at least two of the three conditions for polycystic ovary syndrome based on Rotterdam criteria; age over 18 years, openness of at least one tubal patency based on HSG; normal spermogram; willingness to cooperate in the studying Exclusion criteria: changes in the diagnosis of the patience during the research; hyperprolactinemia; hypothyroidism; existence of other endocrine diseases such as Cushing.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
The number of follicle. Timepoint: 12th day of the cycle. Method of measurement: Measuring the number of ovarian follicles by transvaginal ultrasonography.;Follicle diameter. Timepoint: 12th day of the cycle. Method of measurement: Measuring the follicle diameter by transvaginal ultrasonography.;Endometrial thickness. Timepoint: 12th day of the cycle. Method of measurement: Measuring the endometrial thickness by transvaginal ultrasonography.;Pregnancy. Timepoint: 14 days after the HCG injection into the uterus. Method of measurement: Measurement The BetaHCG testing by blood tests.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAghdas Abdolrazagh Nejad

Mashad University of Medical Sciences

miri.mhamin@gmail.com+98 51 3854 3031

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026