Labor induction for premature rupture of membranes

Clinical trial on the effectiveness of oxytocin and sublingual administration of misoprostol in premature rupture of membranes before the onset of the active phase of labor in term pregnancies

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016042627615N1

Enrollment

Registered

2016-06-01

Start date

2016-06-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

premature rupture of membranes at term. Preterm spontaneous labour with preterm delivery

Interventions

Intervention 1: Intervention group: To received 10 units of oxytocin in 1 L of ringer's lactate solution or normal saline before labor contractions. Intervention 2: Control group: To received 25 µg of

Treatment - Drugs

Intervention group: To received 10 units of oxytocin in 1 L of ringer's lactate solution or normal saline before labor contractions.

Control group: To received 25 µg of misoprostol per 4 h for a maximum of six doses before labor contractions.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criteria: Premature rupture of membranes after 37 weeks of gestation; not being in the active phase of labor; Bishop score below six; cephalic presentation (vertex); singleton pregnancy; no evidence of clinical or laboratory signs confirming chorioamnionitis before the intervention; confirmation of the normal status of the fetal heart. Exclusion criteria: Prior history of uterine scar; placenta previa; unstable status of the fetal heart; non-cephalic presentation; sensitivity to misoprostol; history of glaucoma in misoprostol users; contraindication to vaginal delivery (e.g., narrow pelvis and genital herpes), and 8) parity = 5.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Intervals between drug administration and labor induction,. Timepoint: Measurements the time of delivery contractions create (at least 3 contractions 30 to 45 seconds in 10 minutes) after intervention. Method of measurement: minutes.	—

Secondary

Measure	Time frame
Interval between cervical dilatation and fetal delivery. Timepoint: After cervical dilatation. Method of measurement: minutes.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElham Motamedi

Mashhad University of Medical Sciences

elham_m2003@yahoo.com+98 51 3762 6485

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026