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Effect of local endometrial injury in women with unsuccessful IVF improve on pregnancy rate

Effect of local endometrial injury in women with one and two failure history in IVF cycle on success rate of embryo implantation and pregnancy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT201604261556N89
Enrollment
70
Registered
2016-12-28
Start date
2016-12-24
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility. Admission for harvesting or implantation of ova

Interventions

Intervention 1: In intervention group, patients are treated with Local endometrial injury (LEI) with standard Pipelle biopsy before IVF procedure in luteal phase of menstrual cycle.Then patients are t
Treatment - Other
In intervention group, patients are treated with Local endometrial injury (LEI) with standard Pipelle biopsy before IVF procedure in luteal phase of menstrual cycle.Then patients are treated with incr
Control group: IVF procedure is performed without LEI.

Sponsors

Vice Chancellor for research, Tehran University of Medical Science
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
15 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age<40 years old; normal uterine cavity in hysteroscopy and Hysterosalpingography in last year; BMI<30; one or two IVF failure; not taking OCP or GnRH for FET in past cycle; patient had indication for EI Exclusion criteria: known intrauterine factors in sonography or imaging as fibroma ; endometrial hyperplasia ; cancer; active vaginal and cervical infection; presence of hydrosalpinx or systemic disorders

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pregnancy. Timepoint: 2 weeks after IVF. Method of measurement: beta HCG test.;Implantation. Timepoint: 5 weeks after IVF. Method of measurement: sonography.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSoodeh Khorasani

Tehran University of Medical Science

soodeh.khorasani@yahoo.com+98 21 7771 9922

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026