Comparing Dexmedetomidine and Morphine used Patient-Controlled Analgesia pump Method on controlling the side effects of Cardiac Surgery

A Comparison between the effects of Dexmedetomidine and Morphine used by patient-controlled anesthesia pump Method on controlling the side effects of Post-operative coronary bypass surgery in intensive care unit at Bushehr heart center in 1394 to 1395

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016042427565N1

Enrollment

Registered

2017-04-10

Start date

2016-04-03

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: general anesthesia. Condition 2: cardiac surgery. Anaesthetic, unspecified Unspecified complication of procedure

Interventions

Intervention 1: Intervention group: Dexmedetomidine 200 micro gram in 100 cc Normal Saline plus 4 mg Ondansetron in Patient-Controlled Anesthesia pump with infusion rate of 0.7 micro gram per kilogram

Treatment - Drugs

Intervention group: Dexmedetomidine 200 micro gram in 100 cc Normal Saline plus 4 mg Ondansetron in Patient-Controlled Anesthesia pump with infusion rate of 0.7 micro gram per kilogram per hour in the

Control group: Morphine 10 milligram with 4 mg Ondansetron into pump with infusion rate of 0.015 micro gram per kilogram per hour in the first 24 hours after the surgery

Eligibility

Sex/Gender

All

Age

40 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients undergoing elective coronary artery bypass graft surgery. Exclusion criteria: Ejection fraction percentage less than 35 %; patients who need reoperation in the first 24 hours after the surgery; Drug Addiction; Patients with informed refusal after the explanation of the procedures.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The intensity of analgesia. Timepoint: First 24 hours after surgery. Method of measurement: Visual analogue scale.;Systolic blood pressure. Timepoint: First 24 hours after surgery. Method of measurement: In millimeters of mercury using mercury manometer.;Diastolic blood pressure. Timepoint: First 24 hours after surgery. Method of measurement: In millimeters of mercury using mercury manometer.;Mean arterial pressure. Timepoint: First 24 hours after surgery. Method of measurement: (twice systolic blood pressure+diastolic blood pressure in millimeters of mercury and by mercury barometer) Divided by 2.	—

Measure

Time frame

The intensity of analgesia. Timepoint: First 24 hours after surgery. Method of measurement: Visual analogue scale.;Systolic blood pressure. Timepoint: First 24 hours after surgery. Method of measurement: In millimeters of mercury using mercury manometer.;Diastolic blood pressure. Timepoint: First 24 hours after surgery. Method of measurement: In millimeters of mercury using mercury manometer.;Mean arterial pressure. Timepoint: First 24 hours after surgery. Method of measurement: (twice systolic blood pressure+diastolic blood pressure in millimeters of mercury and by mercury barometer) Divided by 2.

—

Secondary

Measure	Time frame
Sedation level. Timepoint: First 24 hours after surgery. Method of measurement: By Ramsay sedation scale.;Heart rate. Timepoint: First 24 hours after surgery. Method of measurement: Measuring the radial pulse by palpation in one minute.;Nausea and Vomiting. Timepoint: First 24 hours after surgery. Method of measurement: Patient's self complaining.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDoctor Abdol Rasool Anvaripoor

Bushehr Central Heart Department

A.Anvari.p@hotmail.com+98 77333321925

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026