The effect of intravenous adminstration of lidocaine and lidocaine + mepridine on reduction of propofol induced pain during intravenous injection

Clinical trial comparison of effect of Intravenous adminstration of Lidocaine with the combination of Mepridine and Lidocaine on reduction of Propofol induced pain on patients candidate for General Surgeries.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016042315281N8

Enrollment

150

Registered

2016-06-10

Start date

2015-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complications of anasthesia. Other complications of anaesthesia

Interventions

Intervention 1: Control group:First group,5 cc normal saline 0.9 , 1 minute before propofol injection. Intervention 2: Interventional group:Second gruop,40 mg Lidocaine +25 mg Mepridine (5cc),1 minute

Treatment - Drugs

Control group:First group,5 cc normal saline 0.9 , 1 minute before propofol injection

Interventional group:Second gruop,40 mg Lidocaine +25 mg Mepridine (5cc),1 minute before propofol injection

Interventional group:Third group,40 mg Lidocaine (5cc),1 minute before propofol injection

Eligibility

Sex/Gender

All

Age

16 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion critria:Patients of 16 to 65 y/o addmited for general surgery Exclusion criteria: Patients who recieved sedative drugs 24h before operation;Have drug allergy;With Neurological or Mental disorders;Drug Addicts;Pregnant Women;Who require of rapid induction of anesthesia and Who recieved long term steriod therapy.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The pain measurement of intravenous injection of Propofol if previously usage intravenous injected Lidocaine. Timepoint: 1 minute after injection of Lidocaine,Propofol injected and evaluate the pain. Method of measurement: Fill questionare and visual scale.;The measurement of intravenous injection of intravenous combination of Lidocaine and Mepridine. Timepoint: 1 minute after injection of lidocaine and mepridine,Propofol injected and evaluate pain. Method of measurement: Fill questionare and visual scale.	—

Measure

Time frame

The pain measurement of intravenous injection of Propofol if previously usage intravenous injected Lidocaine. Timepoint: 1 minute after injection of Lidocaine,Propofol injected and evaluate the pain. Method of measurement: Fill questionare and visual scale.;The measurement of intravenous injection of intravenous combination of Lidocaine and Mepridine. Timepoint: 1 minute after injection of lidocaine and mepridine,Propofol injected and evaluate pain. Method of measurement: Fill questionare and visual scale.

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Secondary

Measure	Time frame
Dermal side effects. Timepoint: From injection time untill ending of recovery time. Method of measurement: Fill questionare.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Seyed Ebrahim Sadeghi

Marvdasht Motahari Hospital

Esadeghi@sums.ac.ir+98 71 4333 3278

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026