Helicobacter pylori infection. Helicobacter pylori [H.pylori] as the cause of diseases classified to other chapters
Conditions
Interventions
Intervention 1: Intervention group: Patients will receive 10 days sequential therapy [Pantoprazole (40 mg twice daily) plus amoxicillin (1 mg twice daily) for the first 5 days, followed by Pantoprazol
Treatment - Drugs
Intervention group: Patients will receive 10 days sequential therapy [Pantoprazole (40 mg twice daily) plus amoxicillin (1 mg twice daily) for the first 5 days, followed by Pantoprazole (40 mg twice d
Control group: Patients will receive standard 1 to14 days therapy [Pantoprazole (40 mg twice daily), clarithromycin(500 mg) and amoxicillin (1 mg) twice daily].Patients will be asked to attend the cli
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Signing the consent form Aged more than 18 years Requiring to an upper endoscopic evaluation Negative pregnancy test for the female in reproductive age Subjects should not be from nursing staff No treatment for Helicobacter pylori has been received in the past.
Exclusion criteria
Exclusion criteria: People who received any medications for H pylori (Amoxicillin, Clarithromycin, Metronidazole) in the past 4 weeks Undergoing endoscopy for acute gastrointestinal bleeding Allergy to any of the medications used in the treatment of Helicobacter pylori Having a history of esophageal or gastric carcinoma including lymphoma Esophageal varices or undergoing endoscopy for esophageal varices blockage Taking warfarin or clopidogrel Any coagulopathy that prevents a safe biopsy Pregnancy Having a history of Helicobacter pylori infection History of upper gastrointestinal surgery except for Nissen Fundoplication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helicobacter pylori infection treatment. Timepoint: 6 weeks after intervention. Method of measurement: By urea breath test machine. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: During treatment and 6 weeks after referral for Urea Breath Test. Method of measurement: Observation.;Urea Breath Test. Timepoint: 6 weeks after intervention. Method of measurement: By urea breath test machine. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactPardis Vakili
Ahvaz Jundishapur University Of Medical Sciences, Ahvaz, Iran
Outcome results
None listed