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The effect of vaginal cream Prangos ferulacea Brghvnt Trichomonas vaginalis

Comparison of treatment with oral metronidazole vaginal cream Prangos ferulacea with oral metronidazole vaginal cream with placebo in the treatment of Trichomonas vaginalis infection in women

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160423027534N2
Enrollment
90
Registered
2019-01-04
Start date
2019-02-20
Completion date
Unknown
Last updated
2019-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Trichomoniasis vaginit. Trichomonal vulvovaginitis

Interventions

Intervention 1: Intervention group: metronidazole 250 mg orally, 500 mg twice daily (every 12 hours) with food for 7 days with our Prangos ferulacea vaginal cream. Intervention 2: Control group:metro

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
15 Years to 49 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 15-49 year old married women Non pregnant Non breast feeding Non menopause Non smoker Willing to participate in the research Complaine with foamy yellow green discharge Not having vaginal infections Not having unusual vaginal bleeding during the treatment Not intercoursing during the treatment Not using vaginal ointment,suppository or douching from two days before treatment Not having chronic diseases like heart or kidney problems, diabetes, arthoritis Not using broad-spectrum antibiotics, hormones, anticoagulant and immunosuppressive medicine Not having allergic to metronidazole or topical medications

Exclusion criteria

Exclusion criteria: Exclusion criteria: Unwilling to continue to participate in the reseach Not using vaginal ointment for two consecutive days Being allergic to metronidazole or Prangos ferulacea vaginal cream or intolerance to any forms of medicine Having vaginal infections (bacterial vaginosis and candidiasis) having intercourse during in the treatment become pregnant during treatment incomplete questionnaire

Design outcomes

Primary

MeasureTime frame
1- Evaluation of vaginal secretions in terms of color, odor by direct observation.2. Transient trichomoniasis (under microscope) in wet smear. Timepoint: Before interference and 7 days after treatment. Method of measurement: At first, the secretions and symptoms will be examined with direct vision. Then, using sterile cotton swabs, a vaginal discharge was taken and a 10% potassium solution was prepared on a lavender discharge prepared with sterile cotton swabs. And immediately poured a drop of saline samples under a microscope with a magnification of 400 (× 40) was seen moving trophozoite information.;Observe the wet slides with a microscope. Timepoint: Before interference and 7 days after treatment. Method of measurement: With sterile cotton swabs, a sample of the secretions of the side walls of the vagina was removed and immediately underneath the microscope with magnification (× 40). If trichomoniasis is present in wet pearl trophozoites, they are approved.

Secondary

MeasureTime frame
Trichomoniasis vaginitis. Timepoint: En Before the intervention, seven days after start treatment. Method of measurement: Samples are discharge from the sample by using the pH meter Strip, and after wetting the pH Strip, the color will change, and if the pH of the vaginal discharge is between 6-5, a wet test is performed.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAsieh Azadpourmotlagh

Shahid Beheshti University of Medical Sciences

azadpurmotlagh@gmail.com+98 21 8865 5366

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026