Preoperative subpterygeal injection of bevacizumab Vs mitomycin C for pterygium surgery

The comparison of endothelial cell changes, pterygium thickness and recurrence rate between preoperative subpterygeal injection of bevacizumab Vs mitomycin C

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016042227525N1

Enrollment

Registered

2016-07-02

Start date

2016-05-14

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pterygium. Excl.psudopterygium(H11.8)

Interventions

Intervention 1: Group a: 1month preoperative subpterygeal injection of 0.1 cc mitomycin C. Intervention 2: Group b: ? month preoperative subpterygeal injection of 0.1 cc bevacizumab.

Treatment - Drugs

Group a: 1month preoperative subpterygeal injection of 0.1 cc mitomycin C

Group b: ? month preoperative subpterygeal injection of 0.1 cc bevacizumab

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: Primary pterygium Exclusion criteria;: Pregnancy ; history of pterygium surgery; glaucoma; trachoma ; autoimmune disease

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pterygium thickness. Timepoint: Preoperative subpterygeal njection and 1 month after injectin of mitomycin C and bevacizumab. Method of measurement: Anterior segment OCT.;Endothelial cell count. Timepoint: Preoperative subpterygeal injection and 1 ,3, 6 month after pterygium surgery. Method of measurement: Specular microscopy.	—

Secondary

Measure	Time frame
Recurrence rate of pterygium. Timepoint: 6 months after pterygium surgery. Method of measurement: Eye examination with Slit-lamp biomicroscope.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamid khakshoor

Mashhad University of Medical Sciences

Khakshoorh@mums.ac.ir+98 51 3728 5290

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026