Multiple Sclerosis. Demyelinating diseases of the central nervous system
Conditions
Interventions
Intervention 1: Intervention group 1 : 20 hours Cognitive rehabilitation in 3 month period. Intervention 2: Intervention group 2 : Tab Donepezil 10mg daily for 3 month. Intervention 3: Intervention gr
Rehabilitation
Treatment - Drugs
Placebo
Intervention group 1 : 20 hours Cognitive rehabilitation in 3 month period
Intervention group 2 : Tab Donepezil 10mg daily for 3 month
Intervention group 3 :Tab Placebo daily for 3 month
Sponsors
Vice Chancellor Of Rsearch, Isfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: definite diagnosis of MS according to the McDonald criteria by neurologist ; ability to participate in the interview and convey information and their experiences ; desire to participate in the study and necessary cooperation and motivation for interview ; absence of chronic disease other than multiple sclerosis ; age between 20 and 60 years ; having at least read and write education ; lack of renal and hepatic diseases ; non-use of anticholinergic drugs ; patients with Expanded Disability Status Scale up to 5/5 on the criteria of John Kurtzke ; patients with mild to moderate level of memory performance ; study of depression of subjects according to Beck for Primary Care questionnaire to verify the inclusion and omission of severe depression. Exclusion criteria: loss of each conditions during the study inclusion ; lack of desire to continue this research collaboration ; inability to participate in therapy sessions regularly ; relapses of disease during the intervention period that lead to hospitalization in the hospital.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Memory. Timepoint: Before Intervention & 3 month after Intervention. Method of measurement: Autobiographical Memory Test , The Prospective and Retrospective Memory Questionnaire , The Early Motor Questionnaire.;Attention. Timepoint: Before Intervention & 3 month after Intervention. Method of measurement: Digit Span Test.;Depression. Timepoint: Before Intervention & 3 month after Intervention. Method of measurement: Beck for Primary Care questionnaire.;Quality of Life. Timepoint: Before Intervention & 3 month after Intervention. Method of measurement: Quality of Life 54 questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Mahdi Shahpouri
Isfahan University of Medical Sciences , Neurosciences Research Center
Outcome results
None listed