Facial and jaw lesions. Fracture of mandible
Conditions
Interventions
Intervention 1: Intervention group: recipients of exosomes derived from mesenchymal stem cells in the umbilical cord. Patients with mandibular bone fractures who have been referred to the Tabriz Unive
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Jaw dislocation or fracture accompanied with chin and tooth discomfort and edema Having trouble chewing food Tooth misalignment Teeth falling out or coming loose Joint pain in the jaw and trouble expanding the mouth
Exclusion criteria
Exclusion criteria: Individuals with underlying medical conditions Individuals having issues with coagulation Patients who are above 40 and younger than 18 Individuals with a history of asthma and medication allergies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of improvement of maxillofacial lesions. Timepoint: Examination of bone lesions' recovery after 1, 3, and 6 months following exosome injection. Method of measurement: using techniques from microcomputer tomography, histomorphometry, and histology. Additionally, spectroscopy, bone density measurement, and gene expression study of bone morphogenetic proteins (BMP-2). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactTabriz University of Medical Sciences
Tabriz University of Medical Sciences
Outcome results
None listed