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The effect of vaginal probiotic capsule on fertility in women

The effect of vaginal probiotic capsule on fertility in women with recurrent implantation failure: Clinical Trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160422027520N21
Enrollment
200
Registered
2023-01-24
Start date
2023-02-19
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recurrent implantation failure. Complication associated with artificial fertilization, unspecified

Interventions

Intervention group: Vaginal probiotic capsule (Three months before embryo transfer, two tablets a day vaginally). Provage vaginal probiotic capsule

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Patients from East Azerbaijan Having at least three implantation failures after IVF/ICSI Having primary infertility The thickness of the endometrium on the day of ovulation induction with HCG should be less than 6 mm Having regular menstrual cycles BMI under 30 Do not have any type of immunotherapy in their medical history.

Exclusion criteria

Exclusion criteria: Patients under 18 years old and over 41 years old Having polycystic ovarian syndrome Poor ovarian reserve Having chromosomal abnormalities Positive HIV, HCV or HBV tests Patients with intrauterine anomalies. Patients with coagulation problems.

Design outcomes

Primary

MeasureTime frame
Pregnancy rate. Timepoint: After positive beta-hCG test, clinical pregnancy was evaluated at 5-6 week. Method of measurement: Examining the formation of gestational sac using Sonography method.;Live birth rate. Timepoint: 9 months. Method of measurement: People with positive ß-hCG test after treatment will be continuously monitored with the help of gynecologists. After about 9 months, we will evaluate the number of babies born.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Yousefi

Tabriz University of Medical Sciences

mehdi_yusefi@yahoo.com+98 41 3336 4665

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026