Recurrent implantation failure. Complication associated with artificial fertilization, unspecified
Conditions
Interventions
Intervention 1: Intervention group: probiotic tablets (2 tablets per day) orally. Intervention 2: Control group: receive no intervention.
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Patients from East Azerbaijan Having at least three implantation failures Do not have any type of immunotherapy in their medical history. Having regular menstrual cycles
Exclusion criteria
Exclusion criteria: Patients under 18 years old and over 41 years old Patients with coagulation problems. Patients with intrauterine anomalies. Having chromosomal abnormalities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The frequency of Th1 and Th2 cells. Timepoint: Before and after interference. Method of measurement: By using flow cytometry.;Investigating the expression level of transcription factors T-bet and GATA3. Timepoint: Before and after interference. Method of measurement: By using Quantitative Real time PCR.;Examining the expression level of cytokines IL-4, IL-10, IFN?, TNFa. Timepoint: Before and after interference. Method of measurement: By using Quantitative Real time PCR.;Investigating the secretion of cytokines IL-4, IL-10, IFN?, TNFa. Timepoint: Before and after interference. Method of measurement: using sandwich ELISA method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy rate. Timepoint: After positive beta-hCG test, clinical pregnancy was evaluated at 5-6 week. Method of measurement: Examining the formation of gestational sac using Sonography method. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehdi Yousefi
Tabriz University of Medical Sciences
Outcome results
None listed