Donepezil effect in Executive Function of Hyperactivity Disorder

Comparison of Donepezil and Placebo as adjunctive therapy with Ritalin on Executive Functioning of children with Attention Deficit Hyperactivity Disorder

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016042027506N1

Enrollment

Registered

2016-05-16

Start date

2016-05-04

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

attention deficit hyperactivity disorder. Disturbance of activity and attention Attention deficit: disorder with hyperactivity hyperactivity disorder syndrome with hyperactivity Excl.: hyperkinetic disorder associated with conduct disorder

Interventions

Intervention 1: Intervention group (1): After the initial evaluation(Connor's parent questionnaire, IQ test,CANTAB test) and gaining the consent of the children and their parents, Ritalin medication a

Treatment - Drugs

Intervention group (1): After the initial evaluation(Connor's parent questionnaire, IQ test,CANTAB test) and gaining the consent of the children and their parents, Ritalin medication at 0.5 milligrams

The intervention group (2): After the initial evaluation (Connor's parent questionnaire, IQ test,CANTAB test) and gaining the consent of the children and their parents, Ritalin medication at 0.5 milli

Eligibility

Sex/Gender

All

Age

4 Years to 12 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1. Age of six to twelve years; 2. DSM-5 criteria for a diagnosis of ADHD; 3. IQ above 90. Exclusion criteria: 1. an intervening physical disorder such as neurological disorders, a record of severe allergic reaction to Ritalin or Donepezil, record of heart disease; 2. a major psychiatric disease such as mood disorders, psychotic disorders, substance abuse.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Change in severity of symptoms of Attention Deficit Hyperactivity Disorder, according to the opinion of therapist and family. Timepoint: weeks zero, four, and eight. Method of measurement: Conners Parent Scale and General Clinical Assessment.	—

Secondary

Measure	Time frame
Change in mean scores of the CANTAB computer test of executive functions (working memory, planning skills, capacity of working memory, response inhibition and impulse control, measuring argument). Timepoint: weeks zero, four, and eight. Method of measurement: CANTAB computer test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParisa Pakdel

Tehran University of Medical Science

p-pakdel@razi.tums.ac.ir+98 21 5541 9154

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026