The effect of consuming olive oil in patients with depression

The effect of olive oil consumption on anthropometric indices, blood pressure, inflammatory status and oxidative stress in patients with depression

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016041820140N3

Enrollment

Registered

2016-05-14

Start date

2015-11-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression. Depressive episode

Interventions

Intervention 1: The intervention group: Daily consumption of 25 milliliters extra virgin olive oil for duration of 52 days. Intervention 2: The control group: Daily consumption of 25 milliliters sunfl

Lifestyle

Placebo

The intervention group: Daily consumption of 25 milliliters extra virgin olive oil for duration of 52 days

The control group: Daily consumption of 25 milliliters sunflower oil for duration of 52 days

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Main inclusion criteria: Suffering from major depression based on criteria of Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition; aged 18 to 65 years old; routine consumption of sunflower oil; without allergy to olive or sunflower or their products; without fat malabsorption; a score of less than or equal to 7 in 14-item questionnaire of Mediterranean diet adherence and ability and willingness to participate in the study. Main exclusion criteria: Use of lipid lowering medications; use of corticosteroid medications; suffering from a concurrent serious mental disorder such as schizophrenia; suffering from severe or unstable medical conditions; alcohol or drug dependence; pregnancy; lactation; serious risk of homicide or suicide; the need for hospitalization; change in medications or treatments used for depression; change in diet or physical activity; consumption of less than 70% of the recommended oil and loss of any of the inclusion criteria.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Anthropometric indices (body mass index, waist-to-height ratio). Timepoint: The beginning, middle and end of the study. Method of measurement: Using the weighing scale with the accuracy of 0.1 kg and measuring tapes with the accuracy of 0.1 cm.;Blood pressure. Timepoint: The beginning, middle and end of the study. Method of measurement: In millimeters of mercury using the mercury sphygmomanometer.;Serum high-sensitivity C-reactive protein. Timepoint: The beginning and end of the study. Method of measurement: In milligrams per liter using the assay kit.;Serum malondialdehyde. Timepoint: The beginning and end of the study. Method of measurement: In micromolars using the assay kit.	—

Measure

Time frame

Anthropometric indices (body mass index, waist-to-height ratio). Timepoint: The beginning, middle and end of the study. Method of measurement: Using the weighing scale with the accuracy of 0.1 kg and measuring tapes with the accuracy of 0.1 cm.;Blood pressure. Timepoint: The beginning, middle and end of the study. Method of measurement: In millimeters of mercury using the mercury sphygmomanometer.;Serum high-sensitivity C-reactive protein. Timepoint: The beginning and end of the study. Method of measurement: In milligrams per liter using the assay kit.;Serum malondialdehyde. Timepoint: The beginning and end of the study. Method of measurement: In micromolars using the assay kit.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSahar Foshati

Shiraz University of Medical Sciences

foshatis@sums.ac.ir; s.foshati@gmail.com+98 71 3725 1001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026