Exercise training effects on improving resistance to chemotherapy in patients with breast and gastrointestinal

Exercise training effects on improving resistance to chemotherapy in patients with breast and gastrointestinal cancer: Randomize phase II clinical trail

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016041818745N7

Enrollment

Registered

2016-06-30

Start date

2016-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Breast cancer. Condition 2: colon cancer. Malignant neoplasm of breast Malignant neoplasm of colon

Interventions

Intervention 1: 2- The second group receives only the standard treatments. Intervention 2: 1- The first group receives exercise training with the standard treatments (13 weeks, 3 sessions per week, ea

Treatment - Drugs

Treatment - Other

2- The second group receives only the standard treatments.

1- The first group receives exercise training with the standard treatments (13 weeks, 3 sessions per week, each session 60-90 min)

Eligibility

Sex/Gender

All

Age

30 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria consist: 30-60 year-old women with breast and gastrointestinal cancers; detection of the disease during years 94 and 95; during chemotherapy; by obtaining written consent; lack of response to at least one chemotherapy period (treatment response less than 50%; local recurrence of the disease; the ability of doing exercise training. Exclusion criteria consist: the lack of cardiovascular disease; out of control blood pressure; diabetes; mental illness; infection or immune and endocrine diseases; metastatic disease.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Response to treatment. Timepoint: Destroy of tumor or decrease of tumor size. Method of measurement: CT or MRI.	—

Secondary

Measure	Time frame
Vo2 max , quality of life , and p-gp, ABC, P53, P63, P68, BRCA1 and BRCA2, topoisomerase I and II, Her2, and metallothionein, glutathione and superoxide dismutase. Timepoint: before and after the exercise training. Method of measurement: Questionnaire- Patient records- Blood samples- Western blotting- ELISA- Immunohistochemistry- gene expression.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Ali Mohammad Alizadeh

Cancer Research Center, Cancer Institute of IR. Iran

aalizadeh@sina.tums.ac.ir+98 21 6119 2501

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026