Opioid Poisoning. T40
Conditions
Interventions
Intervention 1: In the intervention group: administration of naloxone (Tolid Daru Company) with the initial dose of 0.04 mg increasing to 0.4- 2, and 10 mg. Intervention 2: In the control group: admin
Treatment - Drugs
In the intervention group: administration of naloxone (Tolid Daru Company) with the initial dose of 0.04 mg increasing to 0.4- 2, and 10 mg
In the control group: administration of naloxone (Tolid Daru Company) with the dose 0.1 mg every 3 minutes to reverse the signs and symptoms of methadone overdose
Sponsors
Toxicological Research Center-?Shahid Beheshti University of Medical Sciences-Vice Chancellor for Re
Eligibility
Sex/Gender
All
Age
12 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Addicted methadone-overdosed patients referring; Positive signs and symptoms of methadone overdose (miosis/respiratory depression/loss of consciousness) Exclusion Criteria: Age younger than 12 years and older than 65 years; previous history of cardiovascular disease; history of respiratory complications due to naloxone; emergent situation that mandates immediate intubation
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reversal of respiratory depression. Timepoint: every 3-5 minutes until reversal of the overdose signs and symptoms. Method of measurement: Check vital signs and VBG. | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurence of withdrawal syndrome. Timepoint: every 5 to 10 minutes. Method of measurement: check of withdrawal signs and symptoms. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Navid Khosravi
Poisoning Ward-Loghman Hakim Hospital
Outcome results
None listed