The effect of Atorvastatin on obsessive compulsive symptoms of refractory Obsessive-compulsive disorder ( add on therapy)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016041527392N1

Enrollment

Registered

2016-06-19

Start date

2014-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive-Compulsive Diorder. The essential feature is recurrent obsessional thoughts or compulsive acts. Obsessional thoughts are ideas, images, or impulses that enter the patient's mind again and again in a stereotyped form. They are almost invariably distressing and the patient oft

Interventions

Intervention 1: Then group 1is treated with atorvastatin at a dose of 20 mg once a day at monthly basis

based on patient's tolerance, the dose is increased 10 mg till it reaches 40 mg per day. The dose is determined on the basis of administration of atorvastatin in patients with hypercholesterolemia . I

Treatment - Drugs

Then group 1is treated with atorvastatin at a dose of 20 mg once a day at monthly basis

based on patient's tolerance, the dose is increased 10 mg till it reaches 40 mg per day. The dose is determined on the basis of administration of atorvastatin in patients with hypercholesterolemia .

The group 2 receives placebo pills. In both groups previous dose of SSRI drugs or clomipramine that patients used to receive, is maintained

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria included patients with religious content OCD; lack of psychosis; the belief in Islam; the lack of mental retardation and physical disabilities and acceptance and cooperation in study from the patient; and exclusion criteria were Unwillingness of the patient to complete the period or fill out the questionnaire; refusing to stay in the study, develop physical debilitating illness during the study so that he/she won't be able to cooperate, move and comprehend.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
ObsessiveAction. Timepoint: Y-BOCS are completed at the end of week 4 and 8. Method of measurement: Y-brown.	—

Secondary

Measure	Time frame
Obsessive Thought. Timepoint: Y-BOCS are completed at the end of week 4 and 8. Method of measurement: Y-brown.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAsiyeh Almasi

The Center of Behavioral Research

as8psyco@gmail.com+98 31 3626 0709

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026