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Reducing complications and treatment of patients with polycystic ovary syndrome

Study the effect of N-acetyl Cysteine (NAC) on apoptotic factors in granulosa cells of women with polycystic ovarian syndrome

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016041227353N1
Enrollment
30
Registered
2016-06-11
Start date
2016-05-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

polycystic ovarian syndrome: PCOS. Sclerocystic ovary syndrome-Stein-Leventhal syndrome

Interventions

Tablets NAC (Alborz ?Darou Pharmaceutical company) - per tablet dose of 600 mg - by three per day - 6 weeks
Placebo (Alborz Darou Pharmaceutical company)- three per day to 6 weeks
Intervention 1: Tablets NAC (Alborz ?Darou Pharmaceutical company) - per tablet dose of 600 mg - by three per day - 6 weeks. Intervention 2: Placebo (Alborz Darou Pharmaceutical company)- three per da
Treatment - Drugs

Sponsors

Vice chancellor for research, Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
25 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for patients: Diagnosis of PCOS according to the Rotterdam criteria, aged between 25 and 35 years, the lack of Oral contraceptive pill (OCP) and hormone analogues Apart from progesterone , The use of assisted reproductive medicine at the same dose in all cases, the absence of other systemic diseases known, the first IVF cycle in patients. exclusion criteria for patients : Hyperprolactinemia, thyroid disease, congenital adrenal hyperplasia, testosterone-secreting tumors, Cushing, endometriosis, FSH above 10 IU / L on the third day after menstrual bleeding, Use of drugs that affect the metabolism of carbohydrates, using an analog of the hormone progesterone than three months before entering the study and severe kidney and liver diseases.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Apoptosis. Timepoint: 6 weeks after intervention. Method of measurement: Real Time PCR.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Azvan

Iran University of Medical Sciences

shirazi.r@iums.ac.ir+98 21 8670 2542

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026