Diabetic nephropathy. Other specified diabetes mellitus with diabetic nephropathy
Conditions
Interventions
Intervention 1: Intervention group: 46 patients in the intervention group will receive mirtazapine (manufactured by Tekajeh Pharmaceutical Company) at a dose of 15mg at night before bedtime. During th
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age above 18 years Diabetic nephropathy Proteinuria less than 3 grams per 24 hours Body Mass Index less than 30 Fasting blood sugar between 80 and 130. Hemoglobin (glycated)A1c between 7and 9
Exclusion criteria
Exclusion criteria: Alcohol consumption Antipsychotic and antidepressant drugs concumption Taking drugs with effect on proteinuria except statins, Angiotensin-Converting Enzyme inhibitor(ACEi) and Angiotensin II Receptor Blocker(ARBs) Not receiving ACEIs and ARBs Antiarrhythmic drugs consumption Movement disorders Leukopenia or thrombocytopenia and taking drugs that cause it Pregnancy Lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proteinuri. Timepoint: Before the intervention and three months after its initiation. Method of measurement: 24h urine.;Fasting blood sugar level. Timepoint: Before the start of the intervention, one month after the start of the intervention, two months after the start of the intervention, and at the end of the intervention. Method of measurement: Enzymatic glucose oxidase method.;Glycated hemoglobin (A1C). Timepoint: Before the intervention and three months after the intervention. Method of measurement: High-performance liquid chromatography (HPLC) method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Appetite level. Timepoint: Pre-intervention and three months after intervention initiation. Method of measurement: Simplified nutritional appetite questionnaire (SNAQ)questionnaire.;Sleep amount. Timepoint: Pre-intervention and three months after intervention initiation. Method of measurement: Pittsburgh sleep quality index questionnare(PSQI).;Creatinine. Timepoint: Before the start of the intervention, one month after the start of the intervention, two months after the start of the intervention, at the end of the intervention. Method of measurement: Jaffe method.;Blood urea nitrogen. Timepoint: Before the start of the intervention, one month after the start of the intervention, two months after the start of the intervention, at the end of the intervention. Method of measurement: Enzymatic(urease) method.;Thyroid hormone T4. Timepoint: Before the start of the intervention, one month after the start of the intervention, two months after the start of the intervention, at the end of the intervention. Method of measurement: Immunoassay method.;Na. Timepoint: Before the start of the intervention, one month after the start of the intervention, two months after the start of the intervention, at the end of the intervention. Method of measurement: Ion-Selective Electrod method.;Alanine aminotransferase (ALT). Timepoint: Before the start of the intervention, one month after the start of the intervention, two months after the start of the intervention, at the end of the intervention. Method of measurement: Spectrophotometric methods.;Potassium. Timepoint: Before the start of the intervention, one month after the start of the intervention, two months after the start of the intervention, at the end of the intervention. Method of measurement: Ion-Selective electrod method.;High-density lipoprotein. Timepoint: Before the start of the intervention, one month after the start of the intervention, two months after the start of the intervention, at the end of the intervention. Method o | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShadi Ziaie Ardestani
Shahid Beheshti University of Medical Sciences
Outcome results
None listed