occult premature ovarian insufficiency. Primary ovarian failure
Conditions
Interventions
Intervention 1: Intervention group: The intervention group will receive one tablet of selenium 200 micrograms daily and one vitamin E 400 units per day for 90 days. Intervention 2: Control group: The
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Accepting informed written consent Women aged 20 to 40 years old Menstrual cycle Having two ovaries There is no evidence of endocrine disorders (diabetes, thyroid disorders, Addison's disease, etc.) by asking the patient and checking out the results of previous patient tests. Occult POI (hormone AMH <1 ng / ml, reduced ovarian reserve, less than 5 anthral follicles, reduced ovarian volume to less than 2.5 cubic centimeters, or all three cases) With BMI <30, the weight and height in this study will be measured by the researcher and the BMI will be calculated according to the formula below. BMI = (WEIGHT (kg)) / (LENGTH (m ^ 2))
Exclusion criteria
Exclusion criteria: Drug Addiction and Smoking The tendency to use donated eggs Having evidence of OVERT POI (FSH> 15 or amenorrhea for more than 3 months) Supplementation of selenium and vitamin E three months before the onset of intervention Having a history of radiotherapy and chemotherapy The use of anticoagulants (co-administration of vitamin E with these drugs increases the risk of bleeding)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentration of anti-mullerian hormone (AMH). Timepoint: Before the intervention begins and 12 months after the intervention begins. Method of measurement: To monitor the level of anti-mullerian hormone, blood sampling will be performed on the day of referral from the Brachial vein and will be immediately transferred to the laboratory and will be used with an ELISA kit.;Number of ovarian antal follicles. Timepoint: Before the intervention begins and 12 months after the intervention begins. Method of measurement: Transvaginal ultrasonography of the ovary on the third day of the menstrual cycle, performed by a radiologist and a device for all participants to check the number of antral follicles. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ovarian volume. Timepoint: Before the intervention begins and 12 months after the intervention begins. Method of measurement: Ovarian volume with the same ultrasound on the third day of menstruation using the following formula Ovarian volume = Length × height × width × p / 6 It will be calculated for each ovary separately.;The incidence of side effects of selenium and vitamin E and their placebo. Timepoint: After the end of the intervention. Method of measurement: The side effects of medicines will be questioned according to the checklist given during supplements or placebo and will be recorded in the checklist. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSafiyeh Farhadi Dizaji
Tabriz University of Medical Sciences
Outcome results
None listed