Effect of Folic acid on reducing appetite caused by the use of methylphenidate in children with attention deficit hyperactivity disorder

Investigating the effect of Folic acid on reducing appetite caused by the use of methylphenidate in children with attention deficit hyperactivity disorder

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016040927304N1

Enrollment

Registered

2016-04-21

Start date

2015-10-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Attention Deficit Hyperactivity Disorder (ADHD). Disturbance of activity and attention

Interventions

Intervention 1: Interventional group: receiving Folic acid (5mg/day) with of methylphenidate (average1 mg/kg) for 8 weeks. Intervention 2: Control group: receiving methylphenidate (average1 mg/kg) wit

Treatment - Drugs

Interventional group: receiving Folic acid (5mg/day) with of methylphenidate (average1 mg/kg) for 8 weeks

Control group: receiving methylphenidate (average1 mg/kg) with placebo for 8 weeks

Eligibility

Sex/Gender

All

Age

6 Years to 12 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients aged between 6 to 12 years old; ADHD diagnosing based on DSMIV; clinical need to treat with methylphenidate; not receiving other pharmacological intervention 2 weeks before the intervention; completing consent form; ability to refer for follow up visits Exclusion criteria: patients with epilepsy and diabetes; cardiovascular disorder; disorder or using drugs that elevate sympathic system activity like Pheochromocytoma; using Pseudoephedrine; psychosis in patient or in their parents; bipolar disorder; using any drugs and supplements which affect weight; low birth weight; history of prematurity; comorbid tourette, celiac, phenylketonuria, autism, mental retardation syndrome; failure to thrive approved in advance by pediatricians; history of severe side effect with the previous use of methylphenidate; mother drug user ;reduced appetite before the study; minor thalassemia

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Appetite score. Timepoint: 0-2-4-6-8 weeks. Method of measurement: questionnaire.	—

Secondary

Measure	Time frame
The weight change. Timepoint: 0-2-4-6-8 weeks. Method of measurement: examination of weight.;The BMI change. Timepoint: 0-2-4-6-8 weeks. Method of measurement: examination of weight and height and standard formula.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Ghazal Salehi Vanani

Ahvaz Jundishapur University of Medical Sciences

Salehivanani.gh@ajums.ac.ir; dr.gh.salehi@gmail.com+98 61 3554 1578

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026