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The effect of ketamine and ondansetron for prevention of shivering after surgery

Comparison between prophylactic low dose ketamine and ondansetron for prevention of shivering after spinal anesthesia for elective cesarean section

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016040627258N1
Enrollment
117
Registered
2016-05-14
Start date
2015-12-06
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

shivering during and after spinal anesthesia. Hypothermia, not associated with low environmental temperature

Interventions

Intervention 1: Intervention group1: Prescription 0.25 mg/kg of ketamin diluted in 10 ml normal saline, intravenously after spinal anesthesia. Intervention 2: Intervention group 2: Prescription 4 mg o
Treatment - Drugs
Placebo
Intervention group1: Prescription 0.25 mg/kg of ketamin diluted in 10 ml normal saline, intravenously after spinal anesthesia.
Intervention group 2: Prescription 4 mg of ondansetron diluted in 10 ml of normal saline, intravenously after spinal anesthesia.
Control group: Prescription 10 ml of normal saline, intravenously after spinal anesthesia.

Sponsors

Vice chancellor For Research Of Ahvaz Jundishapur University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: patients candidate for elective cesarean section with pfannenstiel incision under spinal anesthesia; ASA (American society of anesthesiology) physical class one and two; Patient with ages: 18-40 years old. Exclusion Criteria: history of kidney problems; cardiovascular disease; liver disease; mental illness; seizures; glaucoma; receiving blood products during surgery; lack of patient satisfaction; allergy to ketamine and ondansetron.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Intensity of shivering patients. Timepoint: Every 10 minute to 1 hour after surgery. Method of measurement: Based on the score shivering (0-4).;Systolic blood pressure and diastolic blood pressure. Timepoint: Before administration and every ten minutes to an hour after surgery. Method of measurement: By using the pressure gauge - in millimeters of mercury.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNazli Arbabi

Ahvaz Jundishapur University of Medical Sciences

nazli_arbabi@yahoo.com+98 61 3222 2922

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026