The effects of HRT on cognitive function

The effects of HRT on cognitive function in postmenopausal women

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201604043743N2

Enrollment

140

Registered

2016-07-12

Start date

2016-03-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive dysfunction. Mild cognitive disorder

Interventions

Intervention 1: Intervention group 1: HRT and calcium +D tablet (0.625 mg cojugated estrogen plus 2.5 mg medroxy progestron +calcium D 500 mg + 200 Iu vitamin D) daily for six months. Intervention 2:

Treatment - Drugs

Intervention group 1: HRT and calcium +D tablet (0.625 mg cojugated estrogen plus 2.5 mg medroxy progestron +calcium D 500 mg + 200 Iu vitamin D) daily for six months

Intervention group 2: Calcium +vitamin D tablet (500mg calcium+200 Iu vitamin D) daily for six months

Eligibility

Sex/Gender

Female

Age

48 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: natural menopause; maximum 10 years from menopause, without any contraindication for hormone therapy; no HRT in previous 6 months; without any chronic disease such as cancer psychological diseases; no addiction or smoking; no hyperplasia or myoma in the uterus.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Cognitive function. Timepoint: After 6 months. Method of measurement: MOCA questionnaire.	—

Secondary

Measure	Time frame
Climacteric symptom. Timepoint: After 6 months. Method of measurement: Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaeideh Ziaei

Tarbiat Modares University

ziaei_sa@modares.ac.ir+98 21 8288 3555

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026