Melasma or Chloasma. Other disorders of pigmentation
Conditions
Interventions
Intervention 1: In intervention group: Treatment with cream of solid lipid nano particles containing licorice extracts 4%, BID (day and night) on the lesion along with cream sunscreen SPF=35. Interven
Treatment - Drugs
Placebo
In intervention group: Treatment with cream of solid lipid nano particles containing licorice extracts 4%, BID (day and night) on the lesion along with cream sunscreen SPF=35
In control group: Treatment with cream placebo, BID (day and night) on lesion along with cream sunscreen SPF=35.
Sponsors
Kerman University of Medical Sciences, Deputy of research and technology
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1- Patients with melasma clinically diagnosed 2- Women patients 3- Age between 20 to 40 years old 4- Patients with one lesion at least 5- Those don,t use any treatment for melasma during the six months prior to commencement of the study. Exclusion criteria: 1- Pregnant women 2- Lactating women 3- Those under treatment with other drugs for melasma during the six months prior to commencement of the study 4- Patients with history of allergy to licorice extracts 5- Treatment with oral contraceptives during of the study 6- Those under treatment with any drug for other diseases.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Size of lesions. Timepoint: Before and after intervention. Method of measurement: Examination.;Number of lesions. Timepoint: Before and after intervention. Method of measurement: Examination.;Location of lesions. Timepoint: Before intervention. Method of measurement: Examination.;Quality of life. Timepoint: Before and after intervention. Method of measurement: Questionare MELASQOL and DLQI.;Response to treatment. Timepoint: Before intervention and then at 4, 8 and 12 weeks. Method of measurement: Examination.;Course of the disease. Timepoint: Before intervention. Method of measurement: Questionare.;Wood,s lamp examination. Timepoint: Before intervention. Method of measurement: Examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: After intervention. Method of measurement: Examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSiavash Mohammadzadeh Shanehsaz
Kerman University of Medical Sciences
Outcome results
None listed