impaired blood glucose. Abnormal glucose tolerance test
Conditions
Interventions
Intervention 1: Intervention group: Probiotic yogurt (containing 109 Cfu Lactobacillus Acidophilus LA5 and Bifidobacterium Lactis BB12), 100g daily, from 24th weeks of gestation until delivery. Interv
Prevention
Intervention group: Probiotic yogurt (containing 109 Cfu Lactobacillus Acidophilus LA5 and Bifidobacterium Lactis BB12), 100g daily, from 24th weeks of gestation until delivery
Control group: conventional yogurt, 100g daily, from 24th weeks of gestation until delivery
Sponsors
Research Deputy of Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 20-22 weeks of pregnancy; FBS<92 mg/dl; BMI=25; age= 18 years; able to read and write Exclusion criteria: multiple pregnancy; prior history of GDM; taking any medication likely to influence metabolism of glucose (in particular metformin, glucocorticoids or immunosuppressants); medical condition associated with altered glucose metabolism (in particular Cushing's syndrom/disease and hepatic cirrhosis); known major fetal abnormality; known regular ingestion of other probiotics; smoking; antibiotic intake during current pregnancy
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting blood glucose. Timepoint: Before the intervention, 4 weeks after intervention. Method of measurement: labratory assessment.;Blood glucose level 1 hour after intaking 75g oral glucose. Timepoint: 4 weeks after intervention. Method of measurement: labratory assessment.;Blood glucose level 2 hours after intaking 75g oral glucose. Timepoint: 4 weeks after intervention. Method of measurement: labratory assessment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Gestational diabetes. Timepoint: 4 weeks after intervention and after delivery. Method of measurement: Labratory Assessment.;Peeclampsia. Timepoint: 37th weeks of pregnancy and after delivery. Method of measurement: clinical (blood preassure) & labratory (proteinuria) assessment.;Preterm delivery. Timepoint: after delivery. Method of measurement: medical record assessment.;Birth weight. Timepoint: at birth, 10 days after birth. Method of measurement: medical record assessment, measurment of weight 10-12 days after birth by the researcher.;Macrosomia or Large for gestational age. Timepoint: after delivery. Method of measurement: based on birth weight.;Neonatal death. Timepoint: 30 days after birth. Method of measurement: asking from participant (woman) via calling.;Neonatal billirubine level. Timepoint: 3-5 days after delivery. Method of measurement: labratory assessment. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHanieh Asgharian
Nursing & Midwifery Faculty, Tabriz University of medical science
Outcome results
None listed