Acute renal failure. Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
Conditions
Interventions
Intervention 1: Control group: All patients will be received intravenous hydration (2 liters normal saline From 2 h before to 6 h after contrast intake). Intervention 2: Intervention group: All patien
Causes sustained dilation of both the arterial resistance and conductive vessels. This drug is an anti-angina medication that has the dual properties of nitrate and K+ATP channel agonist.
Treatment - Drugs
Control group: All patients will be received intravenous hydration (2 liters normal saline From 2 h before to 6 h after contrast intake)
Intervention group: All patients will be received Nicorandil 20 mg ?tablet (two hours before contrast intake) plus intravenous hydration (2 liter Normal saline from 2 h before to 6 h after injection
Sponsors
Qom University of Medical Sciences and Health Services Vice chancellor
Eligibility
Sex/Gender
All
Age
20 Years to 90 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria were the existence of at least one risk factor of contrast-induced nephropathy, including 1) Moderate systolic heart failure [30% 75 years 4) Moderate renal insufficiency (1/5mg/ dL 2 mg/dL and preexisting dialysis 6- Exposure to contrast medium 48 h pre- and post-coronary angiography 7- Receive of diuretics, N-acetylcystein, sodium bicarbonate, Theophylline, Dopamine, Fenoldopam and NSAID’S during the study 8- Needs to continuous hydration therapy (e.g., sepsis) 9-severe heart failure (EF<=30%)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum creatinine. Timepoint: Before and 48 h after contrast intake. Method of measurement: laboratory Kit (enzymatic method). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactleili Iranirad
Qom University of Medical Sciences, Qom, Iran
Outcome results
None listed