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Assessment of combined exercise training effect in men with primary hypertension

Assessment of 10 weeks of home- versus gym-based combined exercise training effect on the plasma levels of TXNIP, Insulin Sensitivity and Lipid profiles in men with primary hypertension

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160317027092N2
Enrollment
60
Registered
2020-02-08
Start date
2019-04-21
Completion date
Unknown
Last updated
2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary hypertension. Essential (primary) hypertension

Interventions

Resistance training: The resistance component involved 40 to 50 minutes of eight resistance training exercises for the trunk, upper and lower body (eg, squat, calf raise, leg press, bicep curl, tricep
Resistance training: The resistance component involved 40 to 50 minutes of eight resistance training exercises for the trunk, upper and lower body (eg, sit to stand, calf raise, leg press, bicep curl,

Sponsors

Birjand University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
30 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age range between 30-70 years is allowed. According to a specialist doctor's diagnosis, they have primary hypertension and at least one year has passed since their illness Doctors' permission to participate in an exercise program and no need for a specific drug (calcium channel blockers such as verapamil that significantly decrease TXNIP in Langerhans beta cells) (Poudel & Kafle, 2017), at least until Completion of the research period (10 weeks) is required Do not take more than one type of antihypertensive pill daily Their minimum systolic blood pressure was 140 mmHg and diastolic blood pressure was 90 mmHg. They do not have a history of regular exercise in the six months leading up to the time of the study People should not participate in specific weight loss programs Do not have diabetes, fatty liver, Hypothyroidism or hyperthyroidism, anemia (Hb 1.5 mg / dl creatinine) and Do not have a history of Myocardial infarction, heart attack, cardiac arrhythmia Also do not have ischemic heart disease or unstable angina (Farinatti et al., 2016). This informationwill be obtained through the medical records of individuals. They have no history of any heart surgery

Exclusion criteria

Exclusion criteria: Having bone, muscles, and joints problems that prevent exercise. Have a blood pressure higher than 180 mmHg. Take calcium channel blocker drugs such as verapamil, amlodipine, diltiazem. Smoking or addiction to any drug or alcohol (Moraes et al., 2012). Participate in any other exercise program (recreational or professional) while conducting research. Have no interest in participating in a sports activity program.

Design outcomes

Primary

MeasureTime frame
TXNIP Plasma Level. Timepoint: At the beginning of the study (before the intervention), at the end of the study (after the intervention). Method of measurement: Enzyme – Linked ImmunoSorbent Assay (ELISA kit for TXNIP).;Plasma insulin levels. Timepoint: At the beginning of the study (before the intervention), at the end of the study (after the intervention). Method of measurement: Enzyme – Linked ImmunoSorbent Assay (ELISA kit for insulin).;Fasting glucose. Timepoint: At the beginning of the study (before the intervention), at the end of the study (after the intervention). Method of measurement: Enzymatic method of glucose oxidase.;Plasma triglyceride levels. Timepoint: At the beginning of the study (before the intervention), at the end of the study (after the intervention). Method of measurement: Spectrophotometry (enzymatic colorimetry) using Pars Test kits.;Plasma total cholesterol levels. Timepoint: At the beginning of the study (before the intervention), at the end of the study (after the intervention). Method of measurement: Spectrophotometry (enzymatic colorimetry) using Pars Test kits.;HDL plasma level. Timepoint: At the beginning of the study (before the intervention), at the end of the study (after the intervention). Method of measurement: Spectrophotometry (enzymatic colorimetry) using Pars Test kits.;Blood Pressure Number. Timepoint: At the beginning of the study (before the intervention), at the end of the study (after the intervention). Method of measurement: Mercury Pressure Gauge Device.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Masoudi

The University of Birjand

masoudimaryam290@yahoo.com+98 56 3289 3436

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026