Intracranial injury. Focal brain injury
Conditions
Interventions
Intervention 1: The intervention group will receive a package containing four vials of 500 mg TXA and two sterile syringe size 21.The drug is administered as a loading dose ( 1g TXA added to 100 ml o
Treatment - Drugs
The intervention group will receive a package containing four vials of 500 mg TXA and two sterile syringe size 21.The drug is administered as a loading dose ( 1g TXA added to 100 ml of 0.9% normal sa
The control group will receive a package containing four vials of 500 mg placebo and two sterile syringe size 21.The drug is administered as a loading dose ( 1g Normalsaline added to 100 ml of 0.9% no
Sponsors
Vice challenge for research of Ahvaz Jondishapour University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria : age over 18 years old; attendance to the emergency room within the first 8 hours of the accident; trauma to the head with Intraparenchymal hemorrhage (IPH) on brain CT scan; absence of significant extra-cranial hemorrhage such as intra-abdominal hemorrhage; absence of fracture or deformity of limbs; absence of subarachnoid hemorrhage; absence of hematuria; absence of known coagulopathy; necessity to perform neurosurgery in clinical evaluation and according to neurosurgeon's opinion. Exclusion criteria :Existence of pregnancy; the presence of other types of intracranial hemorrhage other than intraparenchymal hematoma; need to FFP or massive whole blood transfusion; hematuria; presence of subarachnoid hemorrhage; usage of anticoagulant drugs and aspirin.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of bleeding during surgery. Timepoint: during surgery. Method of measurement: Suctioned blood volume measurement. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of hospitalization. Timepoint: After surgery. Method of measurement: according to patient's documents.;Result of functional Test. Timepoint: 28 days after surgery or at time of discharge. Method of measurement: Examinations conducted by researcher.;Duration of surgery. Timepoint: At time of surgery. Method of measurement: Document of patients. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactJavad Mozafari
Ahvaz Jundishapour University of Medical Sciences
Outcome results
None listed