The effect of low dose hCG with GnRH agonist in decreasing rate of ovarian hyper stimulation syndrome in IVF cycles.

The effect of low dose hCG with GnRH agonist in decreasing rate of ovarian hyper stimulation syndrome in IVF cycles in Omid clinic and Shariati hospital in Teharn in 1394 and 1395.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016031427045N1

Enrollment

Registered

2016-05-09

Start date

2015-12-28

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility. Complications associated with artificial fertilization, Hyperstimulation of ovaries

Interventions

Intervention 1: Interventional group receives 150 IU FSH daily from the second day of menses. When the 14 mm follicles is observed in transvaginal ultrasound GnRH antagonist (Cetrorelix) 0.25mg subcut

Prevention

Interventional group receives 150 IU FSH daily from the second day of menses. When the 14 mm follicles is observed in transvaginal ultrasound GnRH antagonist (Cetrorelix) 0.25mg subcutaneously daily i

Control group, receives 150 IU FSH daily from the second day of menses. When the 14 mm follicles is observed in transvaginal ultrasound GnRH antagonist (Cetrorelix) 0.25mg subcutaneously daily is adde

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Infertile women with following conditions: 18-39 year old; Normal FSH level; AMH>3.5 ng/ml; Poly cystic ovary (AFC>24); Previous ovarian hyper stimulation syndrome; in the day of oocyte retrieval the number of follicles bigger than 18mm>16 or Estradiol>4000 pg/ml Exclusion criteria: Maternal age>40 year; Hypothalamic dysfunction.

Exclusion criteria

Exclusion criteria:

Design outcomes

Secondary

Measure	Time frame
Chemical Pregnancy. Timepoint: 14 days after embryonal transfer. Method of measurement: ßhCG titration.;Implantation rate. Timepoint: 4 weeks after embryonal transfer. Method of measurement: Observationl of gestational sac in transvaginal sonography.;Clinical pregnancy rate. Timepoint: 2 weeks after positive pregnancy test. Method of measurement: Observation of gestational sac in transvaginal sonography.	—

Measure

Time frame

Chemical Pregnancy. Timepoint: 14 days after embryonal transfer. Method of measurement: ßhCG titration.;Implantation rate. Timepoint: 4 weeks after embryonal transfer. Method of measurement: Observationl of gestational sac in transvaginal sonography.;Clinical pregnancy rate. Timepoint: 2 weeks after positive pregnancy test. Method of measurement: Observation of gestational sac in transvaginal sonography.

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Primary

Measure	Time frame
Ovarian hyper stimulation syndrome. Timepoint: 2 weeks after embryonal transfer. Method of measurement: Transvaginal ultrasonography and examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Venus Chegini

Tehran University of Medical Sciences, Shariati Hospital

venus_chegini@yahoo.com+98 21 8800 8810

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026