Intracranial injury. Epidural haemorrhage Traumatic subdural haemorrhage
Conditions
Interventions
Intervention 1: The intervention group will receive a package containing four vials of 500 mg TXA or placebo and two sterile syringe size 21.The drug is administered as a loading dose ( 1g TXA added
Treatment - Drugs
The intervention group will receive a package containing four vials of 500 mg TXA or placebo and two sterile syringe size 21.The drug is administered as a loading dose ( 1g TXA added to 100 ml of 0.9
The control group will receive a package containing four vials of 500 mg placebo and two sterile syringe size 21.The drug is administered as a loading dose ( 1g Normal saline 0.9% added to 100 ml o
Sponsors
Ahvaz Jondishapour University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria : age is over 18 years old; -in- eight hours after the accident to the emergency room Golestan is reached; trauma to the head and bleeding intracranial subdural and epidural on a CT scan of the brain; absence of significant cranial bleeding such as intra-abdominal hemorrhage; absence of fracture or deformity of limbs; absence of subarachnoid hemorrhage; absence of hematuria; not known coagulopathy; necessity to perform neurosurgery on clinical status and terms of neurosurgeons. Exclusion criteria : The proof of the existence of pregnancy; The presence of intracranial hemorrhage or subdural and epidural hematoma , along with the ddition; The need to FFP transfusion or injection solid; hematuria; The presence of subarachnoid hemorrhage; anticoagulant drugs and aspirin.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of bleeding during surgery. Timepoint: during surgery. Method of measurement: Suctioned blood volume measurement. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of time of hospitalization. Timepoint: After surgery. Method of measurement: Day.;Result of functional Test. Timepoint: after surgery. Method of measurement: Examinations conducted by researcher.;Duration of surgery. Timepoint: At time of surgery. Method of measurement: Document of patients. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactJavad Mozafari
Ahvaz Jundishapour University of Medical Sciences
Outcome results
None listed