Comparison of fertility outcome in freeze embryo transfer cycles with endometrial preparation by natural cycle or artificial cycle

The comparison of fertility outcome obtained from freeze embryo transfer in natural cycle and estrogen progestrone cycle for endometrial preparation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016031022795N3

Enrollment

140

Registered

2016-04-03

Start date

2015-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: In the natural cycle group patients will be followed with several sonography for seeing dominant follicle more than 18 mm and then 10000 IU HCG will be administrated and 4 days later t

Treatment - Drugs

In the natural cycle group patients will be followed with several sonography for seeing dominant follicle more than 18 mm and then 10000 IU HCG will be administrated and 4 days later the embryos will

On the artificial group in the months before starting the transfer cycle from 21 days of luteal phase GnRh agonist (busereline Merck) at a dose of 0.5mg (500mgr) daily will be started.Then on the 2

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: regular menses; age between 18-40 years old; an ivf cycle less than two years ago; having atleast 2 freeze embryos. Exclusion criteria: abnormal uterine bleeding; any endometrial pathology; history of 3 previous IVF failure; any underlying disease; endometriosis; sever male factor infertility need to TESE and PESA.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy rate. Timepoint: 4 weeks after embryo transfer. Method of measurement: Find gestational sac on transvaginal sonography.	—

Secondary

Measure	Time frame
Chemical pregnancy rate in two group. Timepoint: two weeks after transfer for biochemical pregnancy. Method of measurement: BHCG for biochemical.;Rate of abortion. Timepoint: 12 weeks after transfer for abortion. Method of measurement: physical examination and trans vaginal sonography for abortion.;Clinical pregnancy rate. Timepoint: 4weeks for clinical pregnancy. Method of measurement: trans vaginal sonography for clinical.;Live Birth Rate. Timepoint: 24 weeks after transfer for live birth rate. Method of measurement: following of patients until 26 weeks in pregnancy for live birth rate.	—

Measure

Time frame

Chemical pregnancy rate in two group. Timepoint: two weeks after transfer for biochemical pregnancy. Method of measurement: BHCG for biochemical.;Rate of abortion. Timepoint: 12 weeks after transfer for abortion. Method of measurement: physical examination and trans vaginal sonography for abortion.;Clinical pregnancy rate. Timepoint: 4weeks for clinical pregnancy. Method of measurement: trans vaginal sonography for clinical.;Live Birth Rate. Timepoint: 24 weeks after transfer for live birth rate. Method of measurement: following of patients until 26 weeks in pregnancy for live birth rate.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzieh Ghasemi

Tehran University of Medical Sciences

ghasemi-ma@razi.tums.ac.ir+98 21 7767 0692

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026