Schizophrenia. Schizophrenia
Conditions
Interventions
Intervention 1: In the intervention group all patients who received clozapine daily 300 to 400 mg a day for 3 months receive omega-3 (4 gr/day) for 8 weeks. Intervention 2: In the control group patien
Treatment - Drugs
In the intervention group all patients who received clozapine daily 300 to 400 mg a day for 3 months receive omega-3 (4 gr/day) for 8 weeks
In the control group patients who received clozapine 300 to 400 mg a day for 3 months received placebo for 8 weeks .
Sponsors
Vice chancellor for research, Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients with schizophrenia admitted in Hejazi and Ibn Sina hospital in Mashhad that treated with clozapine and valproate at least 3 months (clozapine dose of 200 to 400 mg); Age 18 years or older; triglyceride levels in the morning between 200 to 499 Milligrams per deciliter; metabolic indices of patients before starting treatment with clozapine and valproate are normal. Exclusion criteria: Pregnancy or Lactation; history of sensitivity to fish oil; use of omega-3 in the past few months; Having obvious bleeding disorders or a history of using heparin and coumarin; The reluctance of patients participating in the study; use of other drugs such as statins; history of consumption or abuse of alcohol or drugs within 6 months from baseline.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Height. Timepoint: baseline and week 8. Method of measurement: meter.;Weight. Timepoint: baseline and week 8. Method of measurement: scale.;Abdominal circumference. Timepoint: baseline and week 8. Method of measurement: meter.;BMI. Timepoint: baseline and week 8. Method of measurement: kg/m2.;Triglyceride levels. Timepoint: baseline and week 8. Method of measurement: blood test.;Cholesterol. Timepoint: baseline and week 8. Method of measurement: blood test.;LDL. Timepoint: baseline and week 8. Method of measurement: blood test.;HDL. Timepoint: baseline and week 8. Method of measurement: blood test.;CRP. Timepoint: baseline and week 8. Method of measurement: blood test.;Inflammatory Mediators. Timepoint: baseline and week 8. Method of measurement: blood test.;CBC. Timepoint: baseline and week 8. Method of measurement: blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Narjes Roudbaraki
Ibn e Sina Hospital
Outcome results
None listed