Comparing the efficacy of long-term and short-term doses of letrozole in ovulation induction among patients with polycystic ovary syndrome

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016030926962N2

Enrollment

200

Registered

2016-05-08

Start date

2016-03-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

polycystic ovary syndrome. E28.2

Interventions

Intervention 1: Evaluation of Gonal gonadotropin follicle size (Karma) 75 units, single subcutaneous injection around the belly button. Intervention 2: Letrozole group long-term (manufactured by SOHA)

Treatment - Drugs

Evaluation of Gonal gonadotropin follicle size (Karma) 75 units, single subcutaneous injection around the belly button

Letrozole group long-term (manufactured by SOHA) that will be received oral letrozole on day 2 or 3 of the cycle up to 10 days for 5 mg (per group of 100 people for 3 cycles)

Short-term letrozole group that will be received oral letrozole on day 3 to 7 of the cycle up to 7.5 mg (per group of 100 people for 3 cycles)

Eligibility

Sex/Gender

Female

Age

18 Years to 38 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age 38-18 years - poly cystic ovary syndrome proven - resistance to clomiphene citrate thyroid -Tested normal - normal prolactin - the absence of other causes of infertility, including male factor - normal Hysterosalpangiography Exclusion criteria: Ovarian Cysts- Follicle-stimulating hormone> 10 - Patients with Ovarian Hyper stimulation Syndrome

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The number of mature follicles. Timepoint: 11 cycle days after intervention. Method of measurement: Vaginal ultrasound.;Endometrial thickness at the time of HCG injection. Timepoint: 11 cycle days after intervention. Method of measurement: Vaginal ultrasound.;The number of Gonal. Timepoint: After intervantion, days 5, 7 and 9 of the cycle. Method of measurement: Vaginal ultrasound.	—

Secondary

Measure	Time frame
Event Pregnancy. Timepoint: After intervention. Method of measurement: Test BHCG.;Abortion rate. Timepoint: After intervention. Method of measurement: Clinical and sonographic reports.;Multiple event. Timepoint: After intervention. Method of measurement: Ultrasound Report.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactTahereh Behroozi Lak

Urmia University of Medical Sciences

t.behrooz2@yahoo.com+98 44 3223 7077

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026