Tyroid cancer. Malignant neoplasm of thyroid gland
Conditions
Interventions
Intervention 1: intervention group (1): taking 80 mg nano-curcumin capsules twice daily from one week before to three weeks after radioiodine therapy. Intervention 2: intervention group (2):taking 40
Treatment - Drugs
Placebo
intervention group (1): taking 80 mg nano-curcumin capsules twice daily from one week before to three weeks after radioiodine therapy.
intervention group (2):taking 40 mg nano-curcumin twice daily,from one week before to three weeks after radioiodine therapy.
Control group:taking placebo capsules twice daily in group 3(Control group)from one week before to three weeks after radioiodine therapy.
Sponsors
Vice chancellor for research, Mashhad University of Medical Sciences. (Primary sponsor)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age between 18 to 65; patients with papillary or follicular thyroid cancer; Desire to join to study Exclusion criteria: previous history of radioiodine therapy; history of head and neck radiotherapy; previous history of thyroid surgery; pregnancy; lactation; history of chronic rheumatologic disease; history of LASIK or PRK on eye or surgery of salivary glands; PT less than normal
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Presence/severity of mucositis. Timepoint: first and third week post drug administration. Method of measurement: observation, physical examination, laboratory assessment.;Changes in taste. Timepoint: one and three weeks post radioiodine therapy. Method of measurement: observation, physical examination.;Xerestomia. Timepoint: one and three weeks post radioiodine therapy. Method of measurement: observation, physical examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood cell count. Timepoint: two and twelve months post radioiodine therapy. Method of measurement: Laboratory test.;Tumour recurrence (local or distant). Timepoint: one year post radioiodine therapy. Method of measurement: Pysical examination, Lab results, Ultra sonography, Whole body iodine scan. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Narjess Ayati
Ghaem Nuclear Medicine Research Center
Outcome results
None listed