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The effect of probiotics on fertility

The effectiveness of probiotics in the fertility of patients with cystic ovary syndrome who are candidates for IVF

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160308026962N6
Enrollment
180
Registered
2025-01-20
Start date
2025-02-03
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovary syndrome. Polycystic ovarian syndrome

Interventions

Intervention 1: Intervention group (Oral Probiotic Capsule): One probiotic capsule will be administered orally daily for one month. From the second month, ovulation-stimulating drugs will be administe
brand name LactoFem, Zist-Takhmir) contains 7 beneficial bacterial strains. Intervention 2: Control group: Ovulation-stimulating drugs will be administered from the third day of the menstrual cycle ac

Sponsors

Oroumia University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Age between 18 and 35 Informed consent Suffering from polycystic ovary syndrome IVF candidate Insensitivity to probiotics Negative male infertility factor

Exclusion criteria

Exclusion criteria: Age less than 18 years More than 35 years old Allergy to probiotics Repeated miscarriages more than 3 times The simultaneous existence of male infertility factor

Design outcomes

Primary

MeasureTime frame
Chemical pregnancy rate. Timepoint: 2 weeks after IVF. Method of measurement: Measurement of serum beta HCG levels. A chemical pregnancy will be confirmed if the serum beta HCG level is above 50 IU/L.;Clinical pregnancy rate. Timepoint: 2 weeks after positive beta HCG test. Method of measurement: Clinical pregnancy will be confirmed by observing fetal heart activity via transvaginal ultrasound.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactTahereh Behrouzi Lak

Oroumia University of Medical Sciences

behroozilak.t@umsu.ac.ir+98 44 3223 4897

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026