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Effect of progesterone and aspirin on refusing uterine artery resistance and pregnancy outcome

Comparison of progesterone and two different doses of aspirin effect on refusing uterine artery resistance and pregnancy outcome

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160308026962N5
Enrollment
200
Registered
2021-12-23
Start date
2022-01-05
Completion date
Unknown
Last updated
2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effect of Progesterone and Aspirin on reducing uterine artery resistance and pregnancy outcome. Aspirin, Progesterone, uterine artery resistance

Interventions

Intervention 1: Intervention group 1: Progesterone suppository recipient once a day for two weeks. Intervention 2: Intervention group 2: 80 mg Aspirin recipient once a day for two weeks. Intervention

Sponsors

Oroumia University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: The patient is in the first 3 months of pregnancy. The women who do not have history of abortion. The women who are not emergency patients. The women who are not pregnant with multiples.

Exclusion criteria

Exclusion criteria: Having a body mass index greater than 30 kg/m2. Having high blood pressure Disagreeing to participate in the study Taking Aspirin in the last week Having Aspirin sensitivity Having Progesterone sensitivity Taking Progesterone in the last week Having a uterine abnormality Having a history of gastrointestinal disease

Design outcomes

Primary

MeasureTime frame
Uterine artery resistance. Timepoint: At the beginning of the study, patients undergoing color Doppler vaginal ultrasounds of the uterine arteries will be placed by a single perinatologist to determine the average PI and RI of the uterine arteries, then they will be given aspirin and progesterone for 2 weeks. At the end of two weeks, the cervical artery vaginal ultrasound will be performed again. The mean changes in the PI and RI of the uterine arteries after taking the medication will be evaluated. Method of measurement: Checklist before and after intervention.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Tahereh Behroozilak

Oroumia University of Medical Sciences

behroozilak.t@umsu.ac.ir+98 44 3346 5079

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026