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The effect of thiopental sodium and propofol in electroconvulsive therapy on seizure duration

Comparative study of the effect of thiopental sodium and propofol in electroconvulsive therapy on seizure duration and threshold changes based on electroencephalogram

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160307026950N71
Enrollment
70
Registered
2025-09-06
Start date
2025-09-22
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Candidate for electroconvulsive therapy. Medical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

Interventions

Intervention 1: First intervention group: In this group, patients receive 0.5 mg/kg of succinylcholine and 2 mg/kg of sodium thiopental before electroconvulsive therapy. Intervention 2: Second interve

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients who are candidates for electroconvulsive therapy (such as patients with schizophrenia, major depression, bipolar disorder in the manic phase) Over the age of 18 Patients who have not responded adequately to medication or the individual/guardian is willing to undergo electroconvulsive therapy Patients who are at serious risk of suicide or harm to others if they do not receive electroconvulsive therapy Consent to participate in the study

Exclusion criteria

Exclusion criteria: Having a recent history of cardiovascular diseases such as myocardial infarction or congestive heart failure Having brain tumors, cerebral aneurysms or any increased intracranial pressure Patients with uncontrolled heart failure Patients at risk of anesthesia (ASA level 4-5)

Design outcomes

Primary

MeasureTime frame
Seizure time. Timepoint: During the electroconvulsive therapy process. Method of measurement: Time in minutes.;Seizure threshold. Timepoint: During the electroconvulsive therapy process. Method of measurement: Based on electrocardiogram (ECG).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Behzad Nazemroaya

Esfahan University of Medical Sciences

behzad_nazem@med.mui.ac.ir+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026