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Comparison of the pretreatment effects of low-dose midazolam, low-dose etomidate, and transcutaneous electrical stimulation in reducing pain

Comparison of the pretreatment effects of low-dose midazolam, low-dose etomidate, and transcutaneous electrical stimulation in reducing pain and myoclonic movements induced by etomidate

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20160307026950N70
Enrollment
92
Registered
2025-06-12
Start date
2025-07-23
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery with general anesthesia.

Interventions

Intervention 1: Control group: In this group, patients will receive 2 cc of normal saline before anesthesia. Intervention 2: First intervention group: In this group, patients will receive 0.15 mg/kg o

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age range 18 to 60 years With ASA I or II Candidate for general surgery with local anesthesia

Exclusion criteria

Exclusion criteria: BMI less than 18 or more than 31 kg/m2 History of heart failure, heart block Liver or kidney disease Dementia History of allergy to any of the drugs used Pregnancy

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: Following the injection of etomidate until the patient is completely anesthetized. Method of measurement: Score 0 (no pain) to 10 (most severe pain).;Myoclonic movements. Timepoint: Following the injection of Etomidate. Method of measurement: Score 0 to 3 (Score 0: no myoclonus, score 1: mild myoclonus (in the wrist only), score 2: moderate myoclonus (in the arm, elbow or shoulder), and score 3: severe myoclonus (generalized response or in more than one limb, apnea, nausea, vomiting and itching)).;Heart rate. Timepoint: Before the injection of Etomidate, immediately after full anesthesia. Method of measurement: Monitoring device.;Mean arterial pressure. Timepoint: Before the injection of Etomidate, immediately after full anesthesia. Method of measurement: Monitoring device.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehzad Nazemroaya

Esfahan University of Medical Sciences

behzad_nazem@med.mui.ac.ir+98 31 3212 3543

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026