Examining the positive efficacy of ketamine over dexamethasone

A comparative study of pre emptive administration of two drugs, ketamine and dexamethasone on pain, nausea and vomiting after abdominal laparoscopic cholecystectomy surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160307026950N68

Enrollment

102

Registered

2025-05-03

Start date

2025-04-08

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

laparoscopic cholecystectomy. ?????????

Interventions

Intervention 1: Intervention group1: The group receiving ketamine at a dose of 0.75 mg/kg. Intervention 2: Intervention group 2: The group receiving dexamethasone at a dose of 0.1 mg/kg. Intervention

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Abdominal laparoscopic cholecystectomy surgery diagnosis Age over 18 years and under 65 years Informed consent to participate in the study

Exclusion criteria

Exclusion criteria: Diabetic patients People with underlying diseases such as diabetes, high blood pressure, primary sclerosing cholangitis Users of other anti-nausea medications Patients with a history of drug and cigarette use, painkillers, nausea and vomiting Any illness accompanied by dizziness and nausea. Patients over 100 kg Patients with motion sickness

Design outcomes

Primary

Measure	Time frame
Vomiting. Timepoint: After Entry to Recovery, every 15 minute until the exit of recovery and then 2,4,8,12 and 24 hours in the first 24 hour after surgery in all 3 group. Method of measurement: Ask the patient.;Pain. Timepoint: After Entry to Recovery, every 15 minute until the exit of recovery and then 2,4,8,12 and 24 hours in the first 24 hour after surgery in all 3 group. Method of measurement: VAS score system.;Systolic blood pressure. Timepoint: Before Anesthesia, after Anesthesia and after injection of Dexamethasone at 1,5,10 minutes and every 15 minute until the end of surgery in all groups. Method of measurement: Non invasive blood pressure measurement.;Diastolic blood pressure. Timepoint: Before Anesthesia, after Anesthesia and after injection of Dexamethasone at 1,5,10 minutes and every 15 minute until the end of surgery in all groups. Method of measurement: Non invasive blood pressure measurement.;Heart rate. Timepoint: Before Anesthesia, after Anesthesia and after injection of Dexamethasone at 1,5,10 minutes and every 15 minute until the end of surgery in all groups. Method of measurement: ECG Monitoring.;Patient satisfaction. Timepoint: First 24 hour after surgery. Method of measurement: Likert scale system (Using a questionnaire to rank, score, and express accurate patient opinions).;Nausea. Timepoint: After Entry to Recovery, every 15 minute until the exit of recovery and then 2,4,8,12 and 24 hours in the first 24 hour after surgery in all 3 group. Method of measurement: Ask the patient.	—

Measure

Time frame

Vomiting. Timepoint: After Entry to Recovery, every 15 minute until the exit of recovery and then 2,4,8,12 and 24 hours in the first 24 hour after surgery in all 3 group. Method of measurement: Ask the patient.;Pain. Timepoint: After Entry to Recovery, every 15 minute until the exit of recovery and then 2,4,8,12 and 24 hours in the first 24 hour after surgery in all 3 group. Method of measurement: VAS score system.;Systolic blood pressure. Timepoint: Before Anesthesia, after Anesthesia and after injection of Dexamethasone at 1,5,10 minutes and every 15 minute until the end of surgery in all groups. Method of measurement: Non invasive blood pressure measurement.;Diastolic blood pressure. Timepoint: Before Anesthesia, after Anesthesia and after injection of Dexamethasone at 1,5,10 minutes and every 15 minute until the end of surgery in all groups. Method of measurement: Non invasive blood pressure measurement.;Heart rate. Timepoint: Before Anesthesia, after Anesthesia and after injection of Dexamethasone at 1,5,10 minutes and every 15 minute until the end of surgery in all groups. Method of measurement: ECG Monitoring.;Patient satisfaction. Timepoint: First 24 hour after surgery. Method of measurement: Likert scale system (Using a questionnaire to rank, score, and express accurate patient opinions).;Nausea. Timepoint: After Entry to Recovery, every 15 minute until the exit of recovery and then 2,4,8,12 and 24 hours in the first 24 hour after surgery in all 3 group. Method of measurement: Ask the patient.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Golestan Hashemi

Esfahan University of Medical Sciences

golestan.hashemi.maryam@gmail.com0313822000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026