The effect of ketamine in reducing pain, nausea, and vomiting in laparoscopic obesity surgery and cholecystectomy

Studying the effect of two-dose ketamine premedication on pain, nausea, and vomiting in laparoscopic obesity surgery and cholecystectomy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160307026950N66

Enrollment

105

Registered

2025-02-14

Start date

2024-12-20

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic Cholecystectomy.

Interventions

Intervention 1: Intervention group A: Those who receive ketamine at a dose of 0.5 mg/kg intravenously before induction of anesthesia. Intervention 2: Intervention group B: Those who receive ketamine a

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Laparoscopic abdominal surgery diagnosis in ASA 1 and 2 patients Age over 18 years and under 65 years Informed consent to participate in the study Candidate for surgery under general anesthesia

Exclusion criteria

Exclusion criteria: Patients with a proven mechanical cause of PONV, such as premature obstruction or ileus Patients with a history of using narcotics and antiemetics Any illness accompanied by dizziness and nausea

Design outcomes

Primary

Measure	Time frame
Nausea. Timepoint: After recovery, every 15 minutes until leaving recovery and then the first 2, 4, 8, 12 and 24 hours after surgery in 3 groups. Method of measurement: Questioning the patient.;Vomiting. Timepoint: After recovery, every 15 minutes until leaving recovery and then the first 2, 4, 8, 12 and 24 hours after surgery in 3 groups. Method of measurement: Questioning the patient.;Pain. Timepoint: After recovery, every 15 minutes until leaving recovery and then the first 2, 4, 8, 12 and 24 hours after surgery in 3 groups. Method of measurement: VAS score system.;Systolic blood pressure. Timepoint: After recovery, every 15 minutes until leaving recovery and then the first 2, 4, 8, 12 and 24 hours after surgery in 3 groups. Method of measurement: Non invasive blood pressure measurement.;Diastolic blood pressure. Timepoint: After recovery, every 15 minutes until leaving recovery and then the first 2, 4, 8, 12 and 24 hours after surgery in 3 groups. Method of measurement: Non invasive blood pressure measurement.;Patient satisfaction. Timepoint: After recovery, every 15 minutes until leaving recovery and then the first 2, 4, 8, 12 and 24 hours after surgery in 3 groups. Method of measurement: Likert scale system.	—

Measure

Time frame

Nausea. Timepoint: After recovery, every 15 minutes until leaving recovery and then the first 2, 4, 8, 12 and 24 hours after surgery in 3 groups. Method of measurement: Questioning the patient.;Vomiting. Timepoint: After recovery, every 15 minutes until leaving recovery and then the first 2, 4, 8, 12 and 24 hours after surgery in 3 groups. Method of measurement: Questioning the patient.;Pain. Timepoint: After recovery, every 15 minutes until leaving recovery and then the first 2, 4, 8, 12 and 24 hours after surgery in 3 groups. Method of measurement: VAS score system.;Systolic blood pressure. Timepoint: After recovery, every 15 minutes until leaving recovery and then the first 2, 4, 8, 12 and 24 hours after surgery in 3 groups. Method of measurement: Non invasive blood pressure measurement.;Diastolic blood pressure. Timepoint: After recovery, every 15 minutes until leaving recovery and then the first 2, 4, 8, 12 and 24 hours after surgery in 3 groups. Method of measurement: Non invasive blood pressure measurement.;Patient satisfaction. Timepoint: After recovery, every 15 minutes until leaving recovery and then the first 2, 4, 8, 12 and 24 hours after surgery in 3 groups. Method of measurement: Likert scale system.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAhmad Shahparifard

Esfahan University of Medical Sciences

ahmad.shahparifard78@gmail.com+98 31 3231 5559

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026