Efficacy of Dexmedetomidine and Ketamine addition to Bupivacaine in reducing postoperative pain in patients undergoing for Lumbosacral spine surgeries

Efficacy of Pre-Emptive Dexmedetomidine and Ketamine addition to Bupivacaine in reducing postoperative pain in patients undergoing for Lumbosacral spine surgeries

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160307026950N63

Enrollment

Registered

2024-10-28

Start date

2024-08-22

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain after lumbar fusion surgery. Other acute postprocedural pain

Interventions

Intervention 1: Intervention group: 20 ml Bupivacaine 0.5 with Ketamine. Intervention 2: Intervention group: 20 ml Bupivacaine 0.5 with Dexmedetomidine.

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Candidate patients for lumbar fusion surgery Age between 18 to 75 years ASA l-ll with anesthesiologist opinion

Exclusion criteria

Exclusion criteria: Known hypersensitivity to local anesthetics or NSAIDs Long-term treatment with opioids Kidney or liver failure Neoplastic disorders Body mass index (BMI) greater than 30 sepsis Unstable cardiomyopathy or pneumopathy Coagulopathies severe diabetes Preoperative psychiatric or cognitive disorders

Design outcomes

Primary

Measure	Time frame
Severity of pain after surgery. Timepoint: 2-6-12-24 hours after surgery. Method of measurement: Visual analog scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehzad Nazemroaya

Esfahan University of Medical Sciences

Behzad_nazem@med.mui.ac.ir+98 31 3668 8597

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026