Comparison of low dose midazolam and etomidate for the Prevention of myoclonic Movements following etomidate Injection.

Comparison of the Effects of Low-Dose Midazolam and Low-Dose etomidate on Prevention of Etomidate-Induced Myoclonus in electroconvulsive therapy

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160307026950N6

Enrollment

120

Registered

2018-07-03

Start date

2017-06-22

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myoclonic Movements.

Interventions

Intervention 1: Intervention group: . Intervention 2: Intervention group: . Intervention 3: Control group: .

Eligibility

Sex/Gender

All

Age

9 Years to 15 Years

Inclusion criteria

Inclusion criteria: All Patients candidate Electroconvulsive Therapy ASA I,ASAII Age 6 - 15 years

Exclusion criteria

Exclusion criteria: Severe cardiovascular disease kidney disease Liver disease Chronic respiratory disease drugs Allergy discontinue of cooperation intubation

Design outcomes

Primary

Measure	Time frame
Myoclonus. Timepoint: After induction anesthesia. Method of measurement: Observation of myoclonic movements (0,1,2,3).;Heart rate changes. Timepoint: Before the intervention, then after the intervention, , 5, 10, 20 minutes after intervention and then After The discharge time of recovery. Method of measurement: Pulse oximetry device.;Mean arterial blood pressure. Timepoint: Before the intervention, then after the intervention, , 5, 10, 20 minutes after intervention and then After The discharge time of recovery. Method of measurement: non invasive blood pressure.;Oxygen saturation. Timepoint: Before the intervention, then after the intervention, , 5, 10, 20 minutes after intervention and then After The discharge time of recovery. Method of measurement: Pulse oximetry device.;Duration of seizure. Timepoint: After intervention. Method of measurement: In seconds using a chronometer.;Recovery Duration. Timepoint: Since entering the recovery section until discharge time. Method of measurement: Minute with using a chronometer.	—

Measure

Time frame

Myoclonus. Timepoint: After induction anesthesia. Method of measurement: Observation of myoclonic movements (0,1,2,3).;Heart rate changes. Timepoint: Before the intervention, then after the intervention, , 5, 10, 20 minutes after intervention and then After The discharge time of recovery. Method of measurement: Pulse oximetry device.;Mean arterial blood pressure. Timepoint: Before the intervention, then after the intervention, , 5, 10, 20 minutes after intervention and then After The discharge time of recovery. Method of measurement: non invasive blood pressure.;Oxygen saturation. Timepoint: Before the intervention, then after the intervention, , 5, 10, 20 minutes after intervention and then After The discharge time of recovery. Method of measurement: Pulse oximetry device.;Duration of seizure. Timepoint: After intervention. Method of measurement: In seconds using a chronometer.;Recovery Duration. Timepoint: Since entering the recovery section until discharge time. Method of measurement: Minute with using a chronometer.

—

Secondary

Measure	Time frame
Nausea and Vomiting. Timepoint: During the stay in the recovery. Method of measurement: In minutes using the chronometer.;Headache. Timepoint: During the stay in the recovery. Method of measurement: Ask the patient about this complication.;Muscle Pain. Timepoint: During the stay in the recovery. Method of measurement: Ask the patient about this complication.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyedeh Maryam Mousavi

Esfahan University of Medical Sciences

smmousavi717@gmail.com+98 313372373

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026