The effect of dexmedetomidine and magnesium sulfate in controlling bleeding in lumbar surgery

A comparative study of the effect of dexmedetomidine and magnesium sulfate administration in controlling bleeding in lumbar laminectomy surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20160307026950N59

Enrollment

Registered

2024-07-16

Start date

2024-08-21

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lumbar fusion surgery. Fusion of spine, lumbar region

Interventions

Intervention 1: First intervention group: In this group, after induction of general anesthesia, 60 mg/kg of magnesium sulfate diluted 50% in 100 cc of normal saline is injected intravenously within 15

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Having indication of lumbar fusion Age 18 to 60 years

Exclusion criteria

Exclusion criteria: Having heart diseases (arrhythmias, heart valve diseases, uncontrolled hypertension) History of respiratory diseases History of preoperative coagulation disorders History of hepatitis History of kidney failure History of diabetes mellitus History of neuromuscular diseases History of seizures Being allergic to any of the drugs used in the study

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: Before induction and then every 30 minutes until the end of surgery. Method of measurement: Monitoring device.;Diastolic blood pressure. Timepoint: Before induction and then every 30 minutes until the end of surgery. Method of measurement: Monitoring device.;Mean arterial pressure. Timepoint: Before induction and then every 30 minutes until the end of surgery. Method of measurement: Monitoring device.;Bleeding. Timepoint: During surgery. Method of measurement: BOEZAAL Scale.	—

Measure

Time frame

Systolic blood pressure. Timepoint: Before induction and then every 30 minutes until the end of surgery. Method of measurement: Monitoring device.;Diastolic blood pressure. Timepoint: Before induction and then every 30 minutes until the end of surgery. Method of measurement: Monitoring device.;Mean arterial pressure. Timepoint: Before induction and then every 30 minutes until the end of surgery. Method of measurement: Monitoring device.;Bleeding. Timepoint: During surgery. Method of measurement: BOEZAAL Scale.

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Secondary

Measure	Time frame
Tachycardia. Timepoint: During surgery. Method of measurement: Monitoring device (30% increase in heart rate compared to baseline).;Bradycardia. Timepoint: During surgery. Method of measurement: Monitoring device (30% decrease in heart rate compared to baseline).;Hypertension. Timepoint: During surgery. Method of measurement: Monitoring device (30% increase in mean arterial pressure compared to baseline).	—

Measure

Time frame

Tachycardia. Timepoint: During surgery. Method of measurement: Monitoring device (30% increase in heart rate compared to baseline).;Bradycardia. Timepoint: During surgery. Method of measurement: Monitoring device (30% decrease in heart rate compared to baseline).;Hypertension. Timepoint: During surgery. Method of measurement: Monitoring device (30% increase in mean arterial pressure compared to baseline).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Behzad Nazemroaya

Esfahan University of Medical Sciences

behzad_nazem@med.mui.ac.ir+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026